BZIP domain


BZIP domain

Pfam_box
Symbol = bZIP_1
Name = bZIP transcription factor



width =220
caption =CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Pfam= PF00170
InterPro= IPR011616
SMART=
PROSITE=PDOC00036
SCOP = 1ysa
TCDB =
OPM family=
OPM protein=
PDB=PDB3|1dh3A:285-339 PDB3|1t2kD:336-395 PDB3|1s9kE:257-308PDB3|1junB:276-313 PDB3|1jnmA:254-313 PDB3|1a02J:257-308PDB3|1swiB:249-278 PDB3|1ce9A:251-279 PDB3|1uo0A:249-279PDB3|1rb5B:249-279 PDB3|1unwB:249-279 PDB3|1vzlB:249-279PDB3|1untA:249-279 PDB3|1zimC:249-279 PDB3|1w5jD:249-279PDB3|1zijA:249-279 PDB3|1rb6A:249-279 PDB3|2ztaA:249-279PDB3|1uo5B:249-279 PDB3|1rb1C:249-279 PDB3|1gclC:249-279PDB3|1w5gB:249-279 PDB3|1w5iA:249-279 PDB3|1uo1A:249-279PDB3|1unuB:249-279 PDB3|1gcmA:249-279 PDB3|1rb4C:249-279PDB3|1uo2B:249-279 PDB3|1ysaD:226-279 PDB3|1unzB:249-279PDB3|1w5kD:249-279 PDB3|1ij1A:249-279 PDB3|1zta :247-279PDB3|1ij0A:249-279 PDB3|1uo3A:249-279 PDB3|1w5hA:249-279PDB3|1ij2A:249-279 PDB3|1dgcA:227-279 PDB3|1w5lB:249-279PDB3|1unyA:249-279 PDB3|2b1fB:251-279 PDB3|2bniB:249-279PDB3|1zilA:249-278 PDB3|1ziiA:249-279 PDB3|1unvB:249-279PDB3|1zikB:249-278 PDB3|1unxA:249-279 PDB3|1ij3B:249-279PDB3|1uo4A:249-279 PDB3|1kqlB:255-279 PDB3|2dgcA:229-277PDB3|1piqA:249-279 PDB3|2b22A:251-279 PDB3|1lvxA:265-294PDB3|1gd2H:74-137 PDB3|1ci6A:280-339

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine and lysine. Proteins containig this domain are transcription factors.

bZIP transcription factors

bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants cite journal |author=Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. |title=The role of bZIP transcription factors in green plant evolution: adaptive features emerging from four founder genes |journal=PLos ONE |volume=3 |issue=8 |pages=e2944 |year=2008 |pmid=18698409 |doi=10.1371/journal.pone.0002944] .

bZIP domain containing proteins

*AP-1 fos/jun heterodimer that forms a transcription factor
*Jun-B transcription factor
*CREB cAMP response element transcription factor
*OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize ("Zea Mays") kernels

Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2;
BATF; BATF2; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4;
CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND;
NFE2; NFE2L2; NFE2L3; SNFT; CREM

External links

* [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=BRLZ bZIP domain entry in the SMART database]
* [http://plntfdb.bio.uni-potsdam.de/v2.0/fam_mem.php?family_id=bZIP Plant bZIP transcription factors]

References


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