RAR-related orphan receptor alpha


RAR-related orphan receptor alpha
RAR-related orphan receptor A

PDB rendering based on 1n83.
Identifiers
Symbols RORA; DKFZp686M2414; MGC119326; MGC119329; NR1F1; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA
External IDs OMIM600825 MGI104661 HomoloGene56594 IUPHAR: NR1F1 GeneCards: RORA Gene
RNA expression pattern
PBB GE RORA 210479 s at tn.png
PBB GE RORA 210426 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6095 19883
Ensembl ENSG00000069667 ENSMUSG00000032238
UniProt P35398 Q3U1P4
RefSeq (mRNA) NM_002943.3 NM_013646.1
RefSeq (protein) NP_002934.1 NP_038674.1
Location (UCSC) Chr 15:
60.78 – 61.52 Mb
Chr 9:
68.5 – 69.24 Mb
PubMed search [1] [2]

RAR-related orphan receptor alpha (ROR-alpha), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene.[1]

Contents

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.[2]

Interactions

RAR-related orphan receptor alpha has been shown to interact with EP300[3] and NME1.[4]

References

  1. ^ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749. 
  2. ^ "Entrez Gene: RORA RAR-related orphan receptor A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6095. 
  3. ^ Lau P, Bailey P, Dowhan DH, Muscat GE (January 1999). "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD". Nucleic Acids Res. 27 (2): 411–20. doi:10.1093/nar/27.2.411. PMC 148194. PMID 9862959. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148194. 
  4. ^ Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107. 

See also

Further reading

External links


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