UniProt


UniProt

UniProt is the "uni"versal "prot"ein resource, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the world's most comprehensive resource on protein information.

The UniProt Consortium

The UniProt Consortium comprises the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). EBI, located at the Wellcome Trust Genome Campus in Hinxton, UK, hosts a large resource of bioinformatics databases and services. SIB, located in Geneva, Switzerland, maintains the ExPASy (Expert Protein Analysis System) servers that are a central resource for proteomics tools and databases. PIR, hosted by the National Biomedical Research Foundation (NBRF) at the Georgetown University Medical Center in Washington, DC, USA, is heir to the oldest protein sequence database, Margaret Dayhoff's Atlas of Protein Sequence and Structure. In 2002, EBI, SIB, and PIR joined forces as the UniProt Consortium.

The Roots of UniProt Databases

Each consortium member is heavily involved in protein database maintenance and annotation. Until recently, EBI and SIB together produced Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database (PIR-PSD). These databases coexisted with differing protein sequence coverage and annotation priorities. Swiss-Prot is recognized as the gold standard of protein annotation, with extensive cross-references, literature citations, and computational analyses provided by expert curators. Recognizing that sequence data were being generated at a pace exceeding Swiss-Prot's ability to keep up, TrEMBL (Translated EMBL Nucleotide Sequence Data Library) was created to provide automated annotations for those proteins not in Swiss-Prot. Meanwhile, PIR maintained the PIR-PSD and related databases, including iProClass, a database of protein sequences and curated families. The consortium members — all dedicated to the same goal of providing expansive and meaningful protein annotation, and all with solid foundations stemming from decades of activity — decided to pool their overlapping (and, importantly, their complementary) resources, efforts, and expertise. The UniProt databases build upon these solid foundations.

Organization of UniProt Databases

UniProt provides four core database:

*The UniProt Knowledgebase (UniProtKB) is the central database of protein sequences with accurate, consistent, and rich sequence and functional annotation.

*The UniProt Reference Clusters (UniRef) databases provide non-redundant reference data collections based on the UniProt knowledgebase in order to obtain complete coverage of sequence space at several resolutions.

*The UniProt Metagenomics and Environmental Sequences database (UniMES) is a repository specifically developed for metagenomic and environmental sequence data.

*The UniProt Archive (UniParc) provides a stable, comprehensive sequence collection without redundant sequences by storing the complete body of publicly available protein sequence data.

Funding for UniProt

UniProt is mainly supported by the National Institutes of Health (NIH) grant 2 U01 HG02712-05. Additional support for the EBI's involvement in UniProt comes from the European Commission (EC)'s FELICS grant (021902RII3) and from the NIH GO grant 2P41HG02273-07. Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science, by the European Commission FELICS grant (021902RII3) and by the PATRIC BRC (NIH/NIAID contract HHSN 266200400035C). PIR activities are also supported by the NIH grants and contracts HHSN266200400061C, NCI-caBIG, and 1R01GM080646-01, and the National Science Foundation (NSF) grant IIS-0430743.

External references

* [http://www.uniprot.org www.uniprot.org]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Uniprot — (universal protein database) ist die größte bioinformatische Datenbank für Proteine aller Lebewesen und Viren, und enthält Informationen über die Proteinfunktion und struktur, sowie Links zu anderen themenrelevanten Datenbanken.[1] Sie kombiniert …   Deutsch Wikipedia

  • UniProt — (universal protein database) ist die größte bioinformatische Datenbank für Proteine aller Lebewesen und Viren, und enthält Informationen über die Proteinfunktion und struktur, sowie Links zu anderen themenrelevanten Datenbanken.[1] Sie kombiniert …   Deutsch Wikipedia

  • UniProt — (de universal protein) es el recurso de proteínas universal, un repositorio central de datos sobre proteínas creado por la combinación de Swiss Prot, TrEMBL y PIR. Esto lo ha convertido en el recurso líder mundial almacenando información sobre… …   Wikipedia Español

  • UniProt — (base de données universelle de protéines) est la plus grande des bases de données informatique pour les protéines de tous les organismes vivants et des virus. Elle fournit des informations sur la fonction des protéines, leur structure ainsi que… …   Wikipédia en Français

  • Metallopeptidase — Metalloproteasen (auch Metallopeptidasen) sind Enzyme, die die Peptidbindungen eines Proteins (Eiweiß) spalten können (Proteolyse), wobei ein Molekül Wasser verbraucht wird (Hydrolyse) und das Wassermolekül von einem oder zwei Metallkationen in… …   Deutsch Wikipedia

  • Metallopeptidasen — Metalloproteasen (auch Metallopeptidasen) sind Enzyme, die die Peptidbindungen eines Proteins (Eiweiß) spalten können (Proteolyse), wobei ein Molekül Wasser verbraucht wird (Hydrolyse) und das Wassermolekül von einem oder zwei Metallkationen in… …   Deutsch Wikipedia

  • Metalloprotease — Metalloproteasen (auch Metallopeptidasen) sind Enzyme, die die Peptidbindungen eines Proteins (Eiweiß) spalten können (Proteolyse), wobei ein Molekül Wasser verbraucht wird (Hydrolyse) und das Wassermolekül von einem oder zwei Metallkationen in… …   Deutsch Wikipedia

  • Metalloproteinase — Metalloproteasen (auch Metallopeptidasen) sind Enzyme, die die Peptidbindungen eines Proteins (Eiweiß) spalten können (Proteolyse), wobei ein Molekül Wasser verbraucht wird (Hydrolyse) und das Wassermolekül von einem oder zwei Metallkationen in… …   Deutsch Wikipedia

  • Metalloproteinasen — Metalloproteasen (auch Metallopeptidasen) sind Enzyme, die die Peptidbindungen eines Proteins (Eiweiß) spalten können (Proteolyse), wobei ein Molekül Wasser verbraucht wird (Hydrolyse) und das Wassermolekül von einem oder zwei Metallkationen in… …   Deutsch Wikipedia

  • Katepsin — Bändermodell des Cathepsin K. Cathepsine (auch Kat(h)epsine von griech. καθεψειν verdauen) sind Enzyme, die beispielsweise in Lysosomen, eosinophilen Granulozyten und Osteoklasten zu finden sind und einen hydrolytischen Abbau der extrazellulären… …   Deutsch Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.