HMGA


HMGA

protein
Name=high mobility group AT-hook 1
caption=


width=
HGNCid=5010
Symbol=HMGA1
AltSymbols=HMGIY
EntrezGene=3159
OMIM=600701
RefSeq=NM_145901
UniProt=P17096
PDB=
ECnumber=
Chromosome=6
Arm=p
Band=21
LocusSupplementaryData=
protein
Name=high mobility group AT-hook 2
caption=


width=
HGNCid=5009
Symbol=HMGA2
AltSymbols=HMGIC
EntrezGene=8091
OMIM=600698
RefSeq=NM_003484
UniProt=P52926
PDB=
ECnumber=
Chromosome=12
Arm=q
Band=15
LocusSupplementaryData=

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".cite journal | author = Mayr C, Hemann MT, Bartel DP | title = Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation | journal = Science | volume = 315 | issue = 5818 | pages = 1576–9 | year = 2007 | pmid = 17322030 | doi = 10.1126/science.1137999 | issn = ] A recent study has shown variations in HMGA2 to have a moderate association with adult height. [cite web |url=http://news.bbc.co.uk/1/hi/health/6975865.stm |title=BBC NEWS | Health | Scientists discover height gene |accessdate=2007-09-03 |format= |work=] cite journal | author = Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM | title = A common variant of HMGA2 is associated with adult and childhood height in the general population | journal = Nat. Genet. | volume = 39 | issue = 10 | pages = 1245–50 | year = 2007 | pmid = 17767157 | doi = 10.1038/ng2121 | issn = ]

ee also

* HMGA1
* HMGA2

References

External links

*


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