Myeloid/lymphoid or mixed-lineage leukemia 3, also known as MLL3, is a human gene.cite web | title = Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3| url =| accessdate = ]

section_title =
summary_text = This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Tan YC, Chow VT |title=Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects. |journal=Cancer Detect. Prev. |volume=25 |issue= 5 |pages= 454–69 |year= 2002 |pmid= 11718452 |doi=
*cite journal | author=Ruault M, Brun ME, Ventura M, "et al." |title=MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. |journal=Gene |volume=284 |issue= 1-2 |pages= 73–81 |year= 2002 |pmid= 11891048 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Goo YH, Sohn YC, Kim DH, "et al." |title=Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 140–9 |year= 2003 |pmid= 12482968 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Fukuda K, Sakakura C, Miyagawa K, "et al." |title=Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation. |journal=Br. J. Cancer |volume=91 |issue= 8 |pages= 1543–50 |year= 2004 |pmid= 15365572 |doi= 10.1038/sj.bjc.6602187
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Kim SC, Sprung R, Chen Y, "et al." |title=Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. |journal=Mol. Cell |volume=23 |issue= 4 |pages= 607–18 |year= 2006 |pmid= 16916647 |doi= 10.1016/j.molcel.2006.06.026
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Cho YW, Hong T, Hong S, "et al." |title=PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. |journal=J. Biol. Chem. |volume=282 |issue= 28 |pages= 20395–406 |year= 2007 |pmid= 17500065 |doi= 10.1074/jbc.M701574200
*cite journal | author=Ahn CH, Yoo NJ, Lee JW, "et al." |title=Absence of MLL3 mutations in colorectal carcinomas of Korean patients. |journal=APMIS |volume=115 |issue= 7 |pages= 859–60 |year= 2007 |pmid= 17614854 |doi= 10.1111/j.1600-0463.2007.apm_696.x

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • MLL3 — Histona lisina N metiltransferasa HUGO 13726 Símbolo MLL3 Símbolos alt. DKFZp686C08112; FLJ12625; FLJ38309; HALR; KIAA1506 …   Wikipedia Español

  • NCOA6 — Nuclear receptor coactivator 6 Identifiers Symbols NCOA6; AIB3; ASC2; KIAA0181; NRC; PRIP; RAP250; TRBP External IDs …   Wikipedia

  • PAXIP1 — PAX interacting (with transcription activation domain) protein 1 Identifiers Symbols PAXIP1; CAGF29; FLJ41049; PACIP1; PAXIP1L; PTIP; TNRC2 External IDs …   Wikipedia

  • UTX (gene) — Ubiquitously transcribed tetratricopeptide repeat, X chromosome, also known as UTX, is a human gene.cite web | title = Entrez Gene: UTX ubiquitously transcribed tetratricopeptide repeat, X chromosome| url =… …   Wikipedia

  • NCOA6 — Coactivador 6 de receptores nucleares HUGO 15936 Símbolo NCOA6 Símbolos alt. HOXA7, ANTP, HOX1.1, PRIP, TRBP, AIB3, ASC2 …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.