EN1 (gene)


EN1 (gene)

Engrailed homeobox 1, also known as EN1, is a human gene.cite web | title = Entrez Gene: EN1 engrailed homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2019| accessdate = ]

PBB_Summary
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summary_text = Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.cite web | title = Entrez Gene: EN1 engrailed homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2019| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Logan C, Hanks MC, Noble-Topham S, "et al." |title=Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. |journal=Dev. Genet. |volume=13 |issue= 5 |pages= 345–58 |year= 1993 |pmid= 1363401 |doi= 10.1002/dvg.1020130505
*cite journal | author=Logan C, Willard HF, Rommens JM, Joyner AL |title=Chromosomal localization of the human homeo box-containing genes, EN1 and EN2. |journal=Genomics |volume=4 |issue= 2 |pages= 206–9 |year= 1989 |pmid= 2567700 |doi=
*cite journal | author=Kozmik Z, Sure U, Rüedi D, "et al." |title=Deregulated expression of PAX5 in medulloblastoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 12 |pages= 5709–13 |year= 1995 |pmid= 7777574 |doi=
*cite journal | author=Köhler A, Logan C, Joyner AL, Muenke M |title=Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21. |journal=Genomics |volume=15 |issue= 1 |pages= 233–5 |year= 1993 |pmid= 8094370 |doi= 10.1006/geno.1993.1045
*cite journal | author=Loomis CA, Harris E, Michaud J, "et al." |title=The mouse Engrailed-1 gene and ventral limb patterning. |journal=Nature |volume=382 |issue= 6589 |pages= 360–3 |year= 1996 |pmid= 8684466 |doi= 10.1038/382360a0
*cite journal | author=Joliot A, Trembleau A, Raposo G, "et al." |title=Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties. |journal=Development |volume=124 |issue= 10 |pages= 1865–75 |year= 1997 |pmid= 9169834 |doi=
*cite journal | author=Mikkola I, Bruun JA, Holm T, Johansen T |title=Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4109–18 |year= 2001 |pmid= 11069920 |doi= 10.1074/jbc.M008882200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Schaefer LK, Wang S, Schaefer TS |title=Functional interaction of Jun and homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43074–82 |year= 2001 |pmid= 11551904 |doi= 10.1074/jbc.M102552200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hori Y, Gu X, Xie X, Kim SK |title=Differentiation of insulin-producing cells from human neural progenitor cells. |journal=PLoS Med. |volume=2 |issue= 4 |pages= e103 |year= 2006 |pmid= 15839736 |doi= 10.1371/journal.pmed.0020103
*cite journal | author=Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A |title=Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2572–80 |year= 2006 |pmid= 16571670 |doi= 10.1091/mbc.E06-01-0052
*cite journal | author=Atit R, Sgaier SK, Mohamed OA, "et al." |title=Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. |journal=Dev. Biol. |volume=296 |issue= 1 |pages= 164–76 |year= 2006 |pmid= 16730693 |doi= 10.1016/j.ydbio.2006.04.449

External links

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