Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor 1, also known as LEF1, is a human gene.

section_title =
summary_text = Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905). [supplied by OMIM] cite web | title = Entrez Gene: LEF1 lymphoid enhancer-binding factor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Waterman ML |title=Lymphoid enhancer factor/T cell factor expression in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 41–52 |year= 2004 |pmid= 15000148 |doi=
*cite journal | author=Skokowa J, Welte K |title=LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue= |pages= 143–51 |year= 2007 |pmid= 17360796 |doi= 10.1196/annals.1392.012
*cite journal | author=Milatovich A, Travis A, Grosschedl R, Francke U |title=Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. |journal=Genomics |volume=11 |issue= 4 |pages= 1040–8 |year= 1992 |pmid= 1783375 |doi=
*cite journal | author=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=
*cite journal | author=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123–32 |year= 1991 |pmid= 1989880 |doi=
*cite journal | author=Waterman ML, Fischer WH, Jones KA |title=A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. |journal=Genes Dev. |volume=5 |issue= 4 |pages= 656–69 |year= 1991 |pmid= 2010090 |doi=
*cite journal | author=Zhou P, Byrne C, Jacobs J, Fuchs E |title=Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 700–13 |year= 1995 |pmid= 7537238 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Prieve MG, Guttridge KL, Munguia JE, Waterman ML |title=The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7654–8 |year= 1996 |pmid= 8631802 |doi=
*cite journal | author=Behrens J, von Kries JP, Kühl M, "et al." |title=Functional interaction of beta-catenin with the transcription factor LEF-1. |journal=Nature |volume=382 |issue= 6592 |pages= 638–42 |year= 1996 |pmid= 8757136 |doi= 10.1038/382638a0
*cite journal | author=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=
*cite journal | author=Bruhn L, Munnerlyn A, Grosschedl R |title=ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 640–53 |year= 1997 |pmid= 9119228 |doi=
*cite journal | author=Brannon M, Gomperts M, Sumoy L, "et al." |title=A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. |journal=Genes Dev. |volume=11 |issue= 18 |pages= 2359–70 |year= 1997 |pmid= 9308964 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Korinek V, Barker N, Willert K, "et al." |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248–56 |year= 1998 |pmid= 9488439 |doi=
*cite journal | author=Prieve MG, Guttridge KL, Munguia J, Waterman ML |title=Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4819–32 |year= 1998 |pmid= 9671491 |doi=
*cite journal | author=Levanon D, Goldstein RE, Bernstein Y, "et al." |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590–5 |year= 1998 |pmid= 9751710 |doi=
*cite journal | author=Hovanes K, Li TW, Waterman ML |title=The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1994–2003 |year= 2000 |pmid= 10756202 |doi=
*cite journal | author=Labbé E, Letamendia A, Attisano L |title=Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8358–63 |year= 2000 |pmid= 10890911 |doi= 10.1073/pnas.150152697
*cite journal | author=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Microphthalmia-associated transcription factor — Identifiers Symbols MITF; MI; WS2; WS2A; bHLHe32 External IDs …   Wikipedia

  • Nerve Growth factor IB — Nuclear receptor subfamily 4, group A, member 1 PDB rendering based on 1cit …   Wikipedia

  • EP300 — See also: p300 CBP coactivator family E1A binding protein p300 PDB rendering based on 1f81 …   Wikipedia

  • Mothers against decapentaplegic homolog 2 — SMAD family member 2 PDB rendering based on 1dev …   Wikipedia

  • TCF7 — Transcription factor 7 (T cell specific, HMG box), also known as TCF7, is a human gene.cite web | title = Entrez Gene: TCF7 transcription factor 7 (T cell specific, HMG box)| url =… …   Wikipedia

  • High mobility group — or HMG is a group of chromosomal proteins that help with transcription, replication, recombination, and DNA repair.cite journal | author = Rajeswari MR, Jain A | title = High mobility group chromosomal proteins, HMGA1 as potential tumour markers… …   Wikipedia

  • High-Mobility-Group-Proteine — Die High Mobility Group oder HMG ist ein Proteinstrukturmotiv und gleichzeitig der Name einer Gruppe von Proteinen, die bei der Transkription, Replikation, Rekombination und DNA Reparatur eine Rolle spielen. Die High Mobility Group Proteine… …   Deutsch Wikipedia

  • LEF — late expression factor; leflunomide; leukokinesis enhancing factor; lupus erythematosus factor; lymphoid enhanced binding factor; lymphoid enhancer factor …   Medical dictionary

  • CEBPE — CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat enhancer binding protein. CEBPE is its human gene.cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url =… …   Wikipedia

  • DVL2 — Dishevelled, dsh homolog 2 (Drosophila) PDB rendering based on 1l6o …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.