Lymphoid enhancer-binding factor 1


Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor 1, also known as LEF1, is a human gene.

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summary_text = Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905). [supplied by OMIM] cite web | title = Entrez Gene: LEF1 lymphoid enhancer-binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51176| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Waterman ML |title=Lymphoid enhancer factor/T cell factor expression in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 41–52 |year= 2004 |pmid= 15000148 |doi=
*cite journal | author=Skokowa J, Welte K |title=LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue= |pages= 143–51 |year= 2007 |pmid= 17360796 |doi= 10.1196/annals.1392.012
*cite journal | author=Milatovich A, Travis A, Grosschedl R, Francke U |title=Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. |journal=Genomics |volume=11 |issue= 4 |pages= 1040–8 |year= 1992 |pmid= 1783375 |doi=
*cite journal | author=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=
*cite journal | author=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123–32 |year= 1991 |pmid= 1989880 |doi=
*cite journal | author=Waterman ML, Fischer WH, Jones KA |title=A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. |journal=Genes Dev. |volume=5 |issue= 4 |pages= 656–69 |year= 1991 |pmid= 2010090 |doi=
*cite journal | author=Zhou P, Byrne C, Jacobs J, Fuchs E |title=Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 700–13 |year= 1995 |pmid= 7537238 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Prieve MG, Guttridge KL, Munguia JE, Waterman ML |title=The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7654–8 |year= 1996 |pmid= 8631802 |doi=
*cite journal | author=Behrens J, von Kries JP, Kühl M, "et al." |title=Functional interaction of beta-catenin with the transcription factor LEF-1. |journal=Nature |volume=382 |issue= 6592 |pages= 638–42 |year= 1996 |pmid= 8757136 |doi= 10.1038/382638a0
*cite journal | author=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=
*cite journal | author=Bruhn L, Munnerlyn A, Grosschedl R |title=ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 640–53 |year= 1997 |pmid= 9119228 |doi=
*cite journal | author=Brannon M, Gomperts M, Sumoy L, "et al." |title=A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. |journal=Genes Dev. |volume=11 |issue= 18 |pages= 2359–70 |year= 1997 |pmid= 9308964 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Korinek V, Barker N, Willert K, "et al." |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248–56 |year= 1998 |pmid= 9488439 |doi=
*cite journal | author=Prieve MG, Guttridge KL, Munguia J, Waterman ML |title=Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4819–32 |year= 1998 |pmid= 9671491 |doi=
*cite journal | author=Levanon D, Goldstein RE, Bernstein Y, "et al." |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590–5 |year= 1998 |pmid= 9751710 |doi=
*cite journal | author=Hovanes K, Li TW, Waterman ML |title=The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1994–2003 |year= 2000 |pmid= 10756202 |doi=
*cite journal | author=Labbé E, Letamendia A, Attisano L |title=Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8358–63 |year= 2000 |pmid= 10890911 |doi= 10.1073/pnas.150152697
*cite journal | author=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=

External links

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