Retinoblastoma-like protein 1

Retinoblastoma-like protein 1

Retinoblastoma-like 1 (p107), also known as RBL1, is a human gene.

section_title =
summary_text = The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: RBL1 retinoblastoma-like 1 (p107)| url =| accessdate = ]

ee also

* Pocket protein family


Further reading

citations =
*cite journal | author=Faha B, Ewen ME, Tsai LH, "et al." |title=Interaction between human cyclin A and adenovirus E1A-associated p107 protein. |journal=Science |volume=255 |issue= 5040 |pages= 87–90 |year= 1992 |pmid= 1532458 |doi=
*cite journal | author=Ewen ME, Xing YG, Lawrence JB, Livingston DM |title=Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. |journal=Cell |volume=66 |issue= 6 |pages= 1155–64 |year= 1991 |pmid= 1833063 |doi=
*cite journal | author=Datta PK, Raychaudhuri P, Bagchi S |title=Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. |journal=Mol. Cell. Biol. |volume=15 |issue= 10 |pages= 5444–52 |year= 1995 |pmid= 7565695 |doi=
*cite journal | author=Zhu L, Zhu L, Xie E, Chang LS |title=Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3552–62 |year= 1995 |pmid= 7791762 |doi=
*cite journal | author=Sardet C, Vidal M, Cobrinik D, "et al." |title=E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2403–7 |year= 1995 |pmid= 7892279 |doi=
*cite journal | author=Kim YW, Otterson GA, Kratzke RA, "et al." |title=Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. |journal=Mol. Cell. Biol. |volume=14 |issue= 11 |pages= 7256–64 |year= 1994 |pmid= 7935440 |doi=
*cite journal | author=Ginsberg D, Vairo G, Chittenden T, "et al." |title=E2F-4, a new member of the E2F transcription factor family, interacts with p107. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2665–79 |year= 1994 |pmid= 7958924 |doi=
*cite journal | author=Beijersbergen RL, Kerkhoven RM, Zhu L, "et al." |title=E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2680–90 |year= 1994 |pmid= 7958925 |doi=
*cite journal | author=Beijersbergen RL, Hijmans EM, Zhu L, Bernards R |title=Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. |journal=EMBO J. |volume=13 |issue= 17 |pages= 4080–6 |year= 1994 |pmid= 8076603 |doi=
*cite journal | author=Dyson N, Dembski M, Fattaey A, "et al." |title=Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. |journal=J. Virol. |volume=67 |issue= 12 |pages= 7641–7 |year= 1993 |pmid= 8230483 |doi=
*cite journal | author=Zhu L, van den Heuvel S, Helin K, "et al." |title=Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. |journal=Genes Dev. |volume=7 |issue= 7A |pages= 1111–25 |year= 1993 |pmid= 8319904 |doi=
*cite journal | author=Ikeda MA, Jakoi L, Nevins JR |title=A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3215–20 |year= 1996 |pmid= 8622916 |doi=
*cite journal | author=Xiao ZX, Ginsberg D, Ewen M, Livingston DM |title=Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4633–7 |year= 1996 |pmid= 8643455 |doi=
*cite journal | author=Vidal M, Brachmann RK, Fattaey A, "et al." |title=Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10315–20 |year= 1996 |pmid= 8816797 |doi=
*cite journal | author=Shao Z, Siegert JL, Ruppert S, Robbins PD |title=Rb interacts with TAF(II)250/TFIID through multiple domains. |journal=Oncogene |volume=15 |issue= 4 |pages= 385–92 |year= 1997 |pmid= 9242374 |doi= 10.1038/sj.onc.1201204
*cite journal | author=Verona R, Moberg K, Estes S, "et al." |title=E2F activity is regulated by cell cycle-dependent changes in subcellular localization. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7268–82 |year= 1997 |pmid= 9372959 |doi=
*cite journal | author=Trimarchi JM, Fairchild B, Verona R, "et al." |title=E2F-6, a member of the E2F family that can behave as a transcriptional repressor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 6 |pages= 2850–5 |year= 1998 |pmid= 9501179 |doi=
*cite journal | author=Sterner JM, Dew-Knight S, Musahl C, "et al." |title=Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2748–57 |year= 1998 |pmid= 9566894 |doi=
*cite journal | author=Woitach JT, Zhang M, Niu CH, Thorgeirsson SS |title=A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. |journal=Nat. Genet. |volume=19 |issue= 4 |pages= 371–4 |year= 1998 |pmid= 9697699 |doi= 10.1038/1258
*cite journal | author=Veal E, Eisenstein M, Tseng ZH, Gill G |title=A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5032–41 |year= 1998 |pmid= 9710587 |doi=

External links


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