Jumonji, AT rich interactive domain 1A, also known as JARID1A, is a human gene.cite web | title = Entrez Gene: JARID1A jumonji, AT rich interactive domain 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5927| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. It was formally known as Retinoblastoma Binding Protein 2 (RBP2). This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: JARID1A jumonji, AT rich interactive domain 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5927| accessdate = ]

This protein was found to be an H3K4 histone demethylase that binds to c-Myc. [cite journal |author=Secombe J, Li L, Carlos L, Eisenman RN |title=The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth |journal=Genes Dev. |volume=21 |issue=5 |pages=537–51 |year=2007 |pmid=17311883 |doi=10.1101/gad.1523007] It was recently renamed to Lysine Demethylase 5A (KDM5A).


Further reading

citations =
*cite journal | author=Defeo-Jones D, Huang PS, Jones RE, "et al." |title=Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. |journal=Nature |volume=352 |issue= 6332 |pages= 251–4 |year= 1991 |pmid= 1857421 |doi= 10.1038/352251a0
*cite journal | author=Kim YW, Otterson GA, Kratzke RA, "et al." |title=Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. |journal=Mol. Cell. Biol. |volume=14 |issue= 11 |pages= 7256–64 |year= 1994 |pmid= 7935440 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Fattaey AR, Helin K, Dembski MS, "et al." |title=Characterization of the retinoblastoma binding proteins RBP1 and RBP2. |journal=Oncogene |volume=8 |issue= 11 |pages= 3149–56 |year= 1993 |pmid= 8414517 |doi=
*cite journal | author=Baens M, Aerssens J, van Zand K, "et al." |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44–52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Mao S, Neale GA, Goorha RM |title=T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. |journal=Oncogene |volume=14 |issue= 13 |pages= 1531–9 |year= 1997 |pmid= 9129143 |doi= 10.1038/sj.onc.1200988
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chan SW, Hong W |title=Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28402–12 |year= 2001 |pmid= 11358960 |doi= 10.1074/jbc.M100313200
*cite journal | author=Sandrock B, Egly JM |title=A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35328–33 |year= 2001 |pmid= 11445587 |doi= 10.1074/jbc.M105570200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Benevolenskaya EV, Murray HL, Branton P, "et al." |title=Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 623–35 |year= 2005 |pmid= 15949438 |doi= 10.1016/j.molcel.2005.05.012
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Tzschach A, Lenzner S, Moser B, "et al." |title=Novel JARID1C/SMCX mutations in patients with X-linked mental retardation. |journal=Hum. Mutat. |volume=27 |issue= 4 |pages= 389 |year= 2006 |pmid= 16541399 |doi= 10.1002/humu.9420
*cite journal | author=Roesch A, Becker B, Schneider-Brachert W, "et al." |title=Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. |journal=J. Invest. Dermatol. |volume=126 |issue= 8 |pages= 1850–9 |year= 2006 |pmid= 16645588 |doi= 10.1038/sj.jid.5700324
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • JARID1A — Demetilasa 5A específica de lisina HUGO 9886 Símbolo JARID1A Símbolos alt. RBBP2; RBP2; KDM5A …   Wikipedia Español

  • Estrogen receptor alpha — Estrogen receptor 1 PDB rendering based on 1a52 …   Wikipedia

  • Ritmo circadiano — En la biología, los ritmos circadianos (del latín circa, que significa cerca y dies, que significa día ) o ritmos biológicos son oscilaciones de las variables biológicas en intervalos regulares de tiempo. Todos los animales, las plantas y… …   Wikipedia Español

  • Proteína del retinoblastoma — Retinoblastoma 1 (including osteosarcoma) HUGO 9884 Símbolo RB1 Símbolos alt. OSRC …   Wikipedia Español

  • LMO2 — LIM domain only 2 HUGO 6642 Símbolo LMO2 Símbolos alt. RBTN2, RBTNL1, RHOM2, TTG2 …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.