Zinc finger E-box binding homeobox 1, also known as ZEB1, is a human gene.cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = ]

section_title =
summary_text = TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991). [supplied by OMIM] cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = ]


Further reading

citations =
*cite journal | author=Williams TM, Montoya G, Wu Y, "et al." |title=The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. |journal=Genomics |volume=14 |issue= 1 |pages= 194–6 |year= 1992 |pmid= 1427828 |doi=
*cite journal | author=Williams TM, Moolten D, Burlein J, "et al." |title=Identification of a zinc finger protein that inhibits IL-2 gene expression. |journal=Science |volume=254 |issue= 5039 |pages= 1791–4 |year= 1992 |pmid= 1840704 |doi=
*cite journal | author=Franklin AJ, Jetton TL, Shelton KD, Magnuson MA |title=BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 10 |pages= 6773–88 |year= 1994 |pmid= 7935395 |doi=
*cite journal | author=Watanabe Y, Kawakami K, Hirayama Y, Nagano K |title=Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. |journal=J. Biochem. |volume=114 |issue= 6 |pages= 849–55 |year= 1994 |pmid= 8138542 |doi=
*cite journal | author=Ikeda K, Halle JP, Stelzer G, "et al." |title=Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 10–8 |year= 1998 |pmid= 9418848 |doi=
*cite journal | author=Turner J, Crossley M |title=Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. |journal=EMBO J. |volume=17 |issue= 17 |pages= 5129–40 |year= 1998 |pmid= 9724649 |doi= 10.1093/emboj/17.17.5129
*cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683–8 |year= 1999 |pmid= 10359772 |doi=
*cite journal | author=Hlubek F, Löhberg C, Meiler J, "et al." |title=Tip60 is a cell-type-specific transcriptional regulator. |journal=J. Biochem. |volume=129 |issue= 4 |pages= 635–41 |year= 2001 |pmid= 11275565 |doi=
*cite journal | author=Locklin RM, Riggs BL, Hicok KC, "et al." |title=Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. |journal=J. Bone Miner. Res. |volume=16 |issue= 12 |pages= 2192–204 |year= 2002 |pmid= 11760832 |doi=
*cite journal | author=Shaheduzzaman S, Krishnan V, Petrovic A, "et al." |title=Effects of HIV-1 Nef on cellular gene expression profiles. |journal=J. Biomed. Sci. |volume=9 |issue= 1 |pages= 82–96 |year= 2002 |pmid= 11810028 |doi=
*cite journal | author=Guaita S, Puig I, Franci C, "et al." |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209–16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200
*cite journal | author=Costantino ME, Stearman RP, Smith GE, Darling DS |title=Cell-specific phosphorylation of Zfhep transcription factor. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 368–73 |year= 2002 |pmid= 12163027 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Postigo AA |title=Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2443–52 |year= 2003 |pmid= 12743038 |doi= 10.1093/emboj/cdg225
*cite journal | author=Postigo AA, Depp JL, Taylor JJ, Kroll KL |title=Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2453–62 |year= 2003 |pmid= 12743039 |doi= 10.1093/emboj/cdg226
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dillner NB, Sanders MM |title=Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades. |journal=DNA Cell Biol. |volume=23 |issue= 1 |pages= 25–34 |year= 2004 |pmid= 14965470 |doi= 10.1089/104454904322745907
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Shimizu S, Krafchak C, Fuse N, "et al." |title=A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. |journal=Am. J. Med. Genet. A |volume=130 |issue= 4 |pages= 372–7 |year= 2005 |pmid= 15384081 |doi= 10.1002/ajmg.a.30267
*cite journal | author=Eger A, Aigner K, Sonderegger S, "et al." |title=DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. |journal=Oncogene |volume=24 |issue= 14 |pages= 2375–85 |year= 2005 |pmid= 15674322 |doi= 10.1038/sj.onc.1208429

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • mir-200 — microRNA secondary structure and sequence conservation Identifiers Symbol mir 200 Rfam …   Wikipedia

  • mir-205 — microRNA secondary structure and sequence conservation Identifiers Symbol mir 205 Rfam …   Wikipedia

  • Fuchs' dystrophy — Classification and external resources Fuchs corneal dystrophy. Light microscopic appearance of the cornea showing numerous excrescences (guttae) on the posterior surface of Descemet s membrane and the presence of cysts in the corneal epithelium… …   Wikipedia

  • Corneal dystrophy (human) — Main article: corneal dystrophy Corneal dystrophy (human) Classification and external resources ICD 10 H18.5 ICD 9 …   Wikipedia

  • Genetic disorder — For a non technical introduction to the topic, see Introduction to genetics. Genetic disorder Classification and external resources MeSH D030342 A genetic disorder is an illness caused by abnormalities in genes or …   Wikipedia

  • Androgen insensitivity syndrome — Classification and external resources AIS results when the function of the androgen receptor (AR) is impaired. The AR protein (pictured) mediates the effects of androgens in the human body. ICD 10 E …   Wikipedia

  • Cleft lip and palate — For other uses, see Cleft. Cleft lip and palate Classification and external resources …   Wikipedia

  • Septo-optic dysplasia — Classification and external resources ICD 10 Q04.4 ICD 9 742.2 …   Wikipedia

  • Tietz syndrome — Not to be confused with Tietze syndrome. Tietz syndrome Classification and external resources ICD 10 E70.3 (ILDS E70.358) OMIM 103500 …   Wikipedia

  • Congenital hypothyroidism — Classification and external resources ICD 10 E00, E03.0, E03.1 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.