ZEB1


ZEB1

Zinc finger E-box binding homeobox 1, also known as ZEB1, is a human gene.cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = ]

PBB_Summary
section_title =
summary_text = TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991). [supplied by OMIM] cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Williams TM, Montoya G, Wu Y, "et al." |title=The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. |journal=Genomics |volume=14 |issue= 1 |pages= 194–6 |year= 1992 |pmid= 1427828 |doi=
*cite journal | author=Williams TM, Moolten D, Burlein J, "et al." |title=Identification of a zinc finger protein that inhibits IL-2 gene expression. |journal=Science |volume=254 |issue= 5039 |pages= 1791–4 |year= 1992 |pmid= 1840704 |doi=
*cite journal | author=Franklin AJ, Jetton TL, Shelton KD, Magnuson MA |title=BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 10 |pages= 6773–88 |year= 1994 |pmid= 7935395 |doi=
*cite journal | author=Watanabe Y, Kawakami K, Hirayama Y, Nagano K |title=Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. |journal=J. Biochem. |volume=114 |issue= 6 |pages= 849–55 |year= 1994 |pmid= 8138542 |doi=
*cite journal | author=Ikeda K, Halle JP, Stelzer G, "et al." |title=Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 10–8 |year= 1998 |pmid= 9418848 |doi=
*cite journal | author=Turner J, Crossley M |title=Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. |journal=EMBO J. |volume=17 |issue= 17 |pages= 5129–40 |year= 1998 |pmid= 9724649 |doi= 10.1093/emboj/17.17.5129
*cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683–8 |year= 1999 |pmid= 10359772 |doi=
*cite journal | author=Hlubek F, Löhberg C, Meiler J, "et al." |title=Tip60 is a cell-type-specific transcriptional regulator. |journal=J. Biochem. |volume=129 |issue= 4 |pages= 635–41 |year= 2001 |pmid= 11275565 |doi=
*cite journal | author=Locklin RM, Riggs BL, Hicok KC, "et al." |title=Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. |journal=J. Bone Miner. Res. |volume=16 |issue= 12 |pages= 2192–204 |year= 2002 |pmid= 11760832 |doi=
*cite journal | author=Shaheduzzaman S, Krishnan V, Petrovic A, "et al." |title=Effects of HIV-1 Nef on cellular gene expression profiles. |journal=J. Biomed. Sci. |volume=9 |issue= 1 |pages= 82–96 |year= 2002 |pmid= 11810028 |doi=
*cite journal | author=Guaita S, Puig I, Franci C, "et al." |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209–16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200
*cite journal | author=Costantino ME, Stearman RP, Smith GE, Darling DS |title=Cell-specific phosphorylation of Zfhep transcription factor. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 368–73 |year= 2002 |pmid= 12163027 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Postigo AA |title=Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2443–52 |year= 2003 |pmid= 12743038 |doi= 10.1093/emboj/cdg225
*cite journal | author=Postigo AA, Depp JL, Taylor JJ, Kroll KL |title=Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2453–62 |year= 2003 |pmid= 12743039 |doi= 10.1093/emboj/cdg226
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dillner NB, Sanders MM |title=Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades. |journal=DNA Cell Biol. |volume=23 |issue= 1 |pages= 25–34 |year= 2004 |pmid= 14965470 |doi= 10.1089/104454904322745907
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Shimizu S, Krafchak C, Fuse N, "et al." |title=A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. |journal=Am. J. Med. Genet. A |volume=130 |issue= 4 |pages= 372–7 |year= 2005 |pmid= 15384081 |doi= 10.1002/ajmg.a.30267
*cite journal | author=Eger A, Aigner K, Sonderegger S, "et al." |title=DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. |journal=Oncogene |volume=24 |issue= 14 |pages= 2375–85 |year= 2005 |pmid= 15674322 |doi= 10.1038/sj.onc.1208429

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