Metastasis associated 1, also known as MTA1, is a human gene.

section_title =
summary_text = This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.cite web | title = Entrez Gene: MTA1 metastasis associated 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Nicolson GL, Nawa A, Toh Y, "et al." |title=Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 19–24 |year= 2003 |pmid= 12650603 |doi=
*cite journal | author=Toh Y, Pencil SD, Nicolson GL |title=Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. |journal=Gene |volume=159 |issue= 1 |pages= 97–104 |year= 1995 |pmid= 7607577 |doi=
*cite journal | author=Toh Y, Pencil SD, Nicolson GL |title=A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 22958–63 |year= 1994 |pmid= 8083195 |doi=
*cite journal | author=Xue Y, Wong J, Moreno GT, "et al." |title=NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 851–61 |year= 1999 |pmid= 9885572 |doi=
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Toh Y, Kuninaka S, Endo K, "et al." |title=Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1. |journal=J. Exp. Clin. Cancer Res. |volume=19 |issue= 1 |pages= 105–11 |year= 2000 |pmid= 10840944 |doi=
*cite journal | author=Nawa A, Nishimori K, Lin P, "et al." |title=Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 202–12 |year= 2000 |pmid= 10967548 |doi=
*cite journal | author=Mazumdar A, Wang RA, Mishra SK, "et al." |title=Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 30–7 |year= 2001 |pmid= 11146623 |doi= 10.1038/35050532
*cite journal | author=Cui Q, Takiguchi S, Matsusue K, "et al." |title=Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=93 |issue= 1-2 |pages= 139–40 |year= 2001 |pmid= 11474200 |doi=
*cite journal | author=Simpson A, Uitto J, Rodeck U, Mahoney MG |title=Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. |journal=Gene |volume=273 |issue= 1 |pages= 29–39 |year= 2001 |pmid= 11483358 |doi=
*cite journal | author=Sasaki H, Moriyama S, Nakashima Y, "et al." |title=Expression of the MTA1 mRNA in advanced lung cancer. |journal=Lung Cancer |volume=35 |issue= 2 |pages= 149–54 |year= 2002 |pmid= 11804687 |doi=
*cite journal | author=Mahoney MG, Simpson A, Jost M, "et al." |title=Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. |journal=Oncogene |volume=21 |issue= 14 |pages= 2161–70 |year= 2002 |pmid= 11948399 |doi= 10.1038/sj.onc.1205277
*cite journal | author=Kumar R, Wang RA, Mazumdar A, "et al." |title=A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. |journal=Nature |volume=418 |issue= 6898 |pages= 654–7 |year= 2002 |pmid= 12167865 |doi= 10.1038/nature00889
*cite journal | author=Yan C, Wang H, Toh Y, Boyd DD |title=Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2309–16 |year= 2003 |pmid= 12431981 |doi= 10.1074/jbc.M210369200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hakimi MA, Dong Y, Lane WS, "et al." |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234–9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200
*cite journal | author=Talukder AH, Mishra SK, Mandal M, "et al." |title=MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11676–85 |year= 2003 |pmid= 12527756 |doi= 10.1074/jbc.M209570200
*cite journal | author=Mishra SK, Mazumdar A, Vadlamudi RK, "et al." |title=MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19209–19 |year= 2003 |pmid= 12639951 |doi= 10.1074/jbc.M301968200
*cite journal | author=Hamatsu T, Rikimaru T, Yamashita Y, "et al." |title=The role of MTA1 gene expression in human hepatocellular carcinoma. |journal=Oncol. Rep. |volume=10 |issue= 3 |pages= 599–604 |year= 2003 |pmid= 12684630 |doi=

External links


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