Michael Stuart Brown


Michael Stuart Brown
Michael Stuart Brown

Born April 13, 1941 (1941-04-13) (age 70)
Brooklyn, New York, USA
Nationality United States
Fields Biology
Alma mater University of Pennsylvania, University of Pennsylvania School of Medicine
Known for Regulation of cholesterol metabolism
Notable awards Nobel Prize in Physiology or Medicine

Michael Stuart Brown (born April 13, 1941) is an American geneticist and Nobel Laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism.

Contents

Life and career

Brown was born in Brooklyn, New York, the son of Evelyn Katz and Harvey Brown.[1] Graduated from Cheltenham High School (Wyncote, PA). Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966. Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - Receptor-mediated endocytosis.

Their findings led to the development of statin drugs, the cholesterol-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States. Their discoveries are improving more lives every year, both in the United States and around the world. New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein prenylation) in cancer. In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L. Goldstein (Co-recipient of 1985 Nobel Prize in Physiology or Medicine).In 1988, Brown received National Medal of Science for his contributions to the world of Medicine.

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the Sterol regulatory element binding proteins (SREBPs). Since 1993, Drs. Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances. Dr. Brown holds The W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine; and is a member of the Board of Scientific Directors at The Scripps Research Institute. Frequently mentioned as a candidate for nationally-prominent positions in scientific administration, Dr. Brown, like his colleague Joseph L. Goldstein, elects to continue hands-on involvement with research, leading a research team that typically includes a dozen doctoral and postdoctoral trainees. He and his colleague are among the most highly-cited scientists in the world.

Brown is also on the prestigious Prix Galien USA Committee that "recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines". The inauguration of the Prix Galien in the US, the equivalent of the Nobel prize in this field, was in September 2007, and the winners were selected by a preeminent scientific and learned committee that included 7 Nobel Laureates of which Dr. Brown was one.

Awards

Key Papers

See also

References

  1. ^ http://persona.rin.ru/eng/view/f/0/17629/brown-brown,-michael
  2. ^ National Science Foundation - The President's National Medal of Science

External links


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Look at other dictionaries:

  • Michael Stuart Brown — (* 13. April 1941 in Brooklyn, New York, USA) ist ein US amerikanischer Genetiker. 1985 erhielt er zusammen mit Joseph L. Goldstein den Nobelpreis für Physiologie oder Medizin „für ihre Entdeckungen betreffend der Regulierung des …   Deutsch Wikipedia

  • Michael Stuart Brown — Michael S. Brown nació en Nueva York el 13 de abril de 1941. Se doctoró en Medicina en la Universidad de Pensilvania en 1967. En 1977 entró a trabajar en el Centro de Enfermedades Genéticas de la Facultad de Medicina de Dallas. Trabaj… …   Wikipedia Español

  • Michael Stuart Brown — Michael Brown Michel Stuart Brown est un médecin américain, prix Nobel de médecine en 1985 avec Joseph Goldstein pour leurs travaux sur la génétique et l enzymologie. Biographie Michel S. Brown est né le 13 avril 1941, à Brooklyn, New York. Il… …   Wikipédia en Français

  • Michael S. Brown — Michael Stuart Brown Michael Stuart Brown (* 13. April 1941 in Brooklyn, New York, USA) ist ein US amerikanischer Genetiker. 1985 erhielt er zusammen mit Joseph L. Goldstein den Nobelpreis für Physiologie oder Medizin für ihre Entdeckung… …   Deutsch Wikipedia

  • Michael S. Brown — Michael Brown Michel Stuart Brown est un médecin américain, prix Nobel de médecine en 1985 avec Joseph Goldstein pour leurs travaux sur la génétique et l enzymologie. Biographie Michel S. Brown est né le 13 avril 1941, à Brooklyn, New York. Il… …   Wikipédia en Français

  • BROWN, MICHAEL STUART — (1941– ), U.S. medical geneticist and Nobel laureate. Brown was born in New York and received his B.A. in chemistry (1962) and his M.D. (1966) from the University of Pennsylvania. He was an intern and resident at the Massachusetts General… …   Encyclopedia of Judaism

  • Brown , Michael Stuart — (1941–) American medical biochemist and geneticist. See Goldstein, Joseph Leonard …   Scientists

  • Brown (Familienname) — Brown ist ein englischer Familienname. Herkunft und Bedeutung Der Name ist die englische Entsprechung des deutschen Namens Braun. Varianten Browne, Broun Bekannte Namensträger Inhaltsverzeichnis A B C D E F G …   Deutsch Wikipedia

  • Stuart (Name) — Stuart ist ein Vorname und Familienname. Inhaltsverzeichnis 1 Varianten 2 Bekannte Namensträger 2.1 Familienname 2.2 Vorname …   Deutsch Wikipedia

  • Michael Brown — ist der Name folgender Personen: Michael Brown (Cutter), US amerikanischer Cutter Michael Brown (Musiker) (* 1949), US amerikanischer Keyboarder Michael Brown (FEMA) (* 1954), amerikanischer Anwalt und Leiter der US Katastrophenschutzbehörde… …   Deutsch Wikipedia


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