- Joshua Lederberg
name = Joshua Lederberg
box_width = 300px
image_width = 150px
caption = Joshua Lederberg speaking at a conference in 1997
May 23, 1925
Montclair, New Jersey
February 02, 2008
Neurospora crassa Bacterial conjugation Dendral AstrobiologyTransduction
Nobel Prize in Physiology or Medicine(1959) National Medal of Science(1989) Presidential Medal of Freedom(2006)
Joshua Lederberg (
May 23, 1925– February 2, 2008) [ [http://newswire.rockefeller.edu/?page=engine&id=710 Joshua Lederberg, Rockefeller University's fifth president, dies at 82] ] was an American molecular biologist known for his work in genetics, artificial intelligence, and space exploration. He was just 33 years old when he won the 1958 Nobel Prize in Physiology or Medicinefor discovering that bacteria can mate and exchange genes [Warwick, K. "The Joshua Lederberg Papers: Profiles in Science, National Library of Medicine", Biography,Volume 24, Number 4, Fall 2001, pp. 978-982] . He shared the prize with Edward L. Tatumand George Beadlewho won for their work with genetics.
In addition to his contributions to
biology, Lederberg did extensive research in artificial intelligence. This included work in the NASAexperimental programs seeking life on Mars and the chemistry expert system Dendral.
Early life and education
Lederberg was born in
Montclair, New Jersey, to Esther Goldenbaum Schulman Lederberg and Rabbi Zvi Hirsch Lederberg, in 1925, and moved to Washington Heights, Manhattanas an infant. [Broad, William J. [http://www.nytimes.com/2008/02/05/us/05lederberg.html?n=Top/Reference/Times%20Topics/Subjects/D/Deaths%20(Obituaries)&pagewanted=all "Joshua Lederberg, 82, a Nobel Winner, Dies"] , " The New York Times", February 5, 2008. Accessed April 22, 2008. "Dr. Lederberg was born May 23, 1925, in Montclair, N.J., to Zvi Hirsch Lederberg, a rabbi, and the former Esther Goldenbaum, who had emigrated from what is now Israel two years earlier. His family moved to the Washington Heights section of Manhattan when he was 6 months old."] He had two younger brothers. Lederberg graduated from Stuyvesant High Schoolin New York Cityat the age of 15 in 1940. [cite web |url=http://nobelprize.org/nobel_prizes/medicine/laureates/1958/lederberg-bio.html |title=Joshua Lederberg - The Nobel Prize in Physiology or Medicine 1958 - Biography | year=1958 |accessdate=2007-10-31] After graduation, he was allowed lab space as part of the American Institute Science Laboratory, a forerunner of the Westinghouse Science Talent Search. He enrolled in Columbia Universityin 1941, majoring in zoology. Under the mentorship of Francis J. Ryan, he conducted biochemical and genetic studies on the bread mold " Neurospora crassa". Intending to receive his MD and fulfill his military service obligations, Lederberg worked as a hospital corpsman during 1943 in the clinical pathology laboratory at St. Albans Naval Hospital, where he examined sailors' blood and stool samples for malaria. He went on to receive his undergraduate degree in 1944.
He began medical studies at Columbia's College of Physicians and Surgeons while continuing to perform experiments. Inspired by
Oswald Avery's discovery of the importance of DNA, Lederberg began to investigate his hypothesis that, contrary to prevailing opinion, bacteria did not simply pass down exact copies of genetic information, making all cells in a lineage essentially clones. After making little progress at Columbia, Lederberg wrote to Edward Tatum, Ryan's post-doctoral mentor, proposing a collaboration. In 1946 and 1947, Lederberg took a leave of absence to study under the mentorship of Tatum at Yale University. Lederberg and Tatum showed that the bacterium" Escherichia coli" entered a sexual phase during which it could share genetic information through bacterial conjugation. [Lederberg, Joshua, E. L. Tatum, "Gene recombination in E. coli", Nature 158 p. 558, October 19, 1946.] With this discovery and some mapping of the "E. coli" chromosome, Lederberg was able to receive his Ph. D. from Yale Universityin 1947.
Instead of returning to Columbia to finish his medical degree, Lederberg chose to accept an offer of an assistant professorship in genetics at the
University of Wisconsin-Madison. He married Esther Miriam Zimmer, who went with him to Wisconsin. She received her doctorate there in 1950.
Lederberg and his graduate student
Norton Zinderwent on to show in 1952 that bacteriophages could transfer genetic information between bacteria in " Salmonella" [Zinder, Norton D. Joshua Lederberg: "Genetic Exchange in Salmonella", Journal of Bacteriology 64(5), November 1952, pp. 679-699] . This process, called transduction, explained how bacteria of different species could gain resistance to the same antibioticvery quickly.
Esther Lederberg published a paper dealing with the discovery of lambda in 1950 [Lederberg, E. M., 1950, "Lysogenicity in Escherichia coli strain K-12", Microbial Genetics Bulletin, 1, pp. 5-9, Jan. 1950, Univ. of Wisconsin [Evelyn Maisel Witkin, Editor] , Ohio State University, ISSN: 0026-2579, call No. 33-M-4, OCLC: 04079516, Accession Number: AEH8282UW] . This was followed in 1952 by papers written by Norton Zinder and Joshua Lederberg dealing with bacteriophage lambda. [From the series "Perspectives: Anecdotal, Historical and Critical Commentaries on Genetics", edited by James F. Crow and William F. Dove: "Replica Plating and Indirect Selection of Bacterial Mutants: Isolation of Preadaptive Mutants in Bacteria by Sib Selection", Genetics 121, pp 395-399, March, 1989]
During her time in Joshua Lederberg's laboratory,
Esther Lederbergalso discovered fertility factor F, later publishing with Joshua Lederberg and Luigi Luca Cavalli-Sforza. In 1956, the Society of Illinois Bacteriologists awarded Joshua Lederberg and Esther Lederberg the Pasteur Medal, for "their outstanding contributions to the fields of microbiology and genetics".
In 1957, Joshua Lederberg founded the Department of Medical Genetics at the University of Wisconsin-Madison.
Post Nobel Prize research
In 1958, Joshua Lederberg received the Nobel Prize and moved to
Stanford Universitywhere he was the founder and chairman of the Department of Genetics. He collaborated with Frank Macfarlane Burnetto study viral antibodies. With the launching of " Sputnik" in 1957, Lederberg became concerned about the biological impact of space exploration. In a letter to the National Academies of Sciences, he outlined his concerns that extraterrestrial microbes might gain entry to Earth onboard spacecraft, causing catastrophic diseases. He also argued that, conversely, microbial contamination of manmade satellites and probes may obscure the search for extraterrestrial life. He advised quarantine for returning astronauts and equipment and sterilization of equipment prior to launch. Teaming up with Carl Sagan, his public advocacy for what he termed exobiologyhelped expand the role of biology in NASA. In the 1960s, he collaborated with Edward Feigenbaumin Stanford's computer science department to develop DENDRAL.
In 1978, he became the president of
Rockefeller University, until he stepped down in 1990 and became professor- emeritusof molecular genetics and informatics at Rockefeller University.
Throughout his career, Lederberg was active as a scientific advisor to the U.S. government. Starting in 1950, he has been a member of various panels of the Presidential Science Advisory Committee. In 1979, he became a member of the U.S.
Defense Science Boardand the chairman of President Jimmy Carter's President's Cancer Panel. In 1989, he received National Medal of Sciencefor his contributions to the scientific world. In 1994, he headed the Department of Defense's Task Force on Persian Gulf War Health Effects, which investigated Gulf War Syndrome.
In 2006, Lederberg was awarded the
Presidential Medal of Freedom.
Lederberg married fellow scientist Esther Miriam Zimmer in 1946; they divorced in 1966. He married psychiatrist Marguerite Stein Kirsch in 1968. He was survived by Marguerite, their daughter, Anne Lederberg, and his stepson, David Kirsch.
* [http://profiles.nlm.nih.gov/BB/ National Library of Medicine - The Joshua Lederberg Papers]
* [http://nobelprize.org/medicine/laureates/1958/lederberg-bio.html Nobel biography]
* [http://www.cdc.gov/eid/content/14/6/981.htm In Memoriam: Joshua Lederberg (1925-2008)]
Wikimedia Foundation. 2010.
Look at other dictionaries:
Joshua Lederberg — (re … Deutsch Wikipedia
Joshua Lederberg — Joshua Lederberg, né à Montclair (New Jersey) le 23 mai 1925, mort le 2 février 2008 à New York, est un généticien et microbiologiste américain, pionnier de la biologie moléculaire. Il a reçu le Prix Nobel de médecine en 1958 avec … Wikipédia en Français
Joshua Lederberg — Nombre Joshua Lederberg … Wikipedia Español
Joshua Lederberg — nació en 1925 en Montclair, New Jersey, Estados Unidos. Se gradúa a los 19 años en el Columbia College de Nueva York. Realiza estudios de Medicina en la Universidad de Columbia, en Nueva York. Realiza su doctorado en la Universidad de… … Enciclopedia Universal
Medizinnobelpreis 1958: George Wells Beadle — Joshua Lederberg — Edward Lawrie Tatum — Der Nobelpreis ging an die drei amerikanischen Wissenschaftler für die Erforschung der Regulation chemischer Vorgänge durch die Gene und die Genetik von Bakterien. Biografien George Wells Beadle, * Wahoo (Nebraska) 22. 10. 1903,✝ Pomona… … Universal-Lexikon
Joshua — ist ein männlicher Vorname. Inhaltsverzeichnis 1 Herkunft und Bedeutung 2 Namensträger 3 Einzelnachweise 4 Siehe auch … Deutsch Wikipedia
Lederberg — bezeichnet: eine Erhebung im Südosten Stuttgarts einen danach benannten Stadtteil im Stadtbezirk Stuttgart Hedelfingen Lederberg ist der Familienname folgender Personen Esther Lederberg (1922–2006), US amerikanische Molekularbiologin und… … Deutsch Wikipedia
Lederberg — is a surname meaning leather mountain in German and may refer to: * Joshua Lederberg * Esther Lederberg … Wikipedia
LEDERBERG, JOSHUA — (1925– ), U.S. geneticist. Born in Montclair, New Jersey and scion of a rabbinical family from Ereẓ Israel, he studied at Columbia University and then at Yale and made a number of important discoveries in microbial genetics. It had previously… … Encyclopedia of Judaism
Lederberg — [ leɪdəbəːg], Joshua, amerikanischer Mikrobiologe, * Montclair (N. J.) 23. 5. 1925; 1947 54 Professor an der University of Wisconsin in Madison, seither an der Stanford University. Durch Kreuzung von Bakterienstämmen wies Lederberg in… … Universal-Lexikon