Susumu Tonegawa


Susumu Tonegawa

Infobox Scientist
name =Susumu Tonegawa
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caption = Susumu Tonegawa
birth_date = birth date and age|1939|09|06
birth_place = Nagoya, Japan
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nationality = Japan
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alma_mater = University of California, San Diego
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known_for = antibody diversity
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prizes = Nobel Prize for Physiology or Medicine in 1987
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Susumu Tonegawa (利根川 進 "Tonegawa Susumu", born September 6, 1939) is a Japanese scientist who won the Nobel Prize for Physiology or Medicine in 1987 for "his discovery of the genetic principle for generation of antibody diversity." Although he won the Nobel Prize for his work in immunology, Tonegawa is a molecular biologist by training. In his later years, he has turned his attention to the molecular and cellular basis of memory formation.

Tonegawa is best known for elucidating the genetic mechanism in the adaptive immune system. To achieve the diversity of antibodies needed to protect against any type of antigen, the immune system would require millions of genes coding for different antibodies, if each antibody was encoded by one gene. Instead, as Tonegawa showed in a landmark series of experiments beginning in 1976, genetic material can rearrange itself to form the vast array of available antibodies. Comparing the DNA of B cells (a type of white blood cell) in embryonic and adult mice, he observed that genes in the mature B cells of the adult mice are moved around, recombined, and deleted to form the diversity of the variable region of antibodies.

Tonegawa was born in Nagoya, Japan and attended the Hibiya High School in Tokyo. [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1987/tonegawa-autobio.html "Autobiography on Nobel official website"] ] He received his bachelor's degree from Kyoto University in 1963. He received his doctorate from the University of California, San Diego. He did post-doctoral work at the Salk Institute in San Diego in the laboratory of Renato Dulbecco, then worked at the Basel Institute for Immunology in Basel, Switzerland, where he performed his landmark immunology experiments. In 1981, he became a professor at the Massachusetts Institute of Technology, and founded and directed the Picower Institute for Learning and Memory at MIT. In 1982, he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Barbara McClintock another Nobel Prize winner in 1983. He is a member of the Scientific Board of Governors at The Scripps Research Institute. He is currently the director of the RIKEN-MIT Center for Neural Circuit Genetics at MIT.

References

External links

* [http://web.mit.edu/biology/www/facultyareas/facresearch/tonegawa.html Faculty Webpage at MIT Biology]
* [http://web.mit.edu/picowercenter/faculty/tonegawa.html Description of research at the Picower Institute for Learning and Memory]
* [http://www.cumc.columbia.edu/horwitz/ The Official Site of Louisa Gross Horwitz Prize]


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Look at other dictionaries:

  • Susumu Tonegawa — Nacimiento 6 de septiembre de 1939 (72 años) Nagoya, Japón Nacionalidad Japón Alma máter Universidad de Kyoto, Universidad de California, San Diego …   Wikipedia Español

  • Susumu Tonegawa — (利根川 進 Tonegawa Susumu, né à Nagoya au Japon, le 6 septembre 1939) est un savant japonais qui a obtenu le Prix Nobel de physiologie ou médecine en 1987 pour « sa découverte du principe génétique de la génération de la diversité des anticorps …   Wikipédia en Français

  • Susumu Tonegawa — (利根川 進) nació en Nagoya, Japón en 1939. Estudió la licenciatura de Medicina en Japón, trabajando en el departamento de Química de la Universidad de Kyoto. En 1963 se traslada a Estados Unidos comenzando a trabajar en el departamento de Biología… …   Enciclopedia Universal

  • Susumu Tonegawa — Tonegawa Susumu (jap. 利根川 進 Tonegawa Susumu, * 6. September 1939 in Nagoya) ist ein japanischer Molekularbiologe und Immunologe. Er erhielt 1986 den Robert Koch Preis und 1987 den Nobelpreis für Medizin für die Entdeckung der genetischen… …   Deutsch Wikipedia

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  • Tonegawa Susumu — (jap. 利根川 進 Tonegawa Susumu, * 6. September 1939 in Nagoya) ist ein japanischer Molekularbiologe und Immunologe. Er erhielt 1981 den Asahi Preis und den Avery Landsteiner Preis, 1983 einen Gairdner Foundation International Award, 1986 den Robert… …   Deutsch Wikipedia

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  • Tonegawa — Tonegawa, Susumu …   Enciclopedia Universal


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