Peter C. Doherty


Peter C. Doherty

Infobox Scientist
name = Peter C. Doherty
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caption = Peter C. Doherty
birth_date = 15 October 1940
birth_place = Brisbane
death_date =
death_place =
residence =
citizenship =
nationality = Australia
ethnicity =
field = medicine immunology
work_institutions = John Curtin School of Medical Research
alma_mater = University of Edinburgh
doctoral_advisor =
doctoral_students =
known_for = major histocompatibility complex
author_abbrev_bot =
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influenced =
prizes = Nobel Prize in Physiology or Medicine in 1996
religion =
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Peter Charles Doherty, AC (born 15 October 1940) is an Australian Veterinary Surgeon and researcher in the field of medicine. He received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine in 1996, and was named Australian of the Year in 1997.

Doherty's research focuses on the immune system, and his Nobel work described how the body's immune cells protect against viruses. He and Rolf M. Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognize their target antigens in combination with major histocompatibility complex (MHC) proteins.

Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses can't reproduce. Zinkernagel and Doherty discovered that, in order for killer T cells to recognize infected cells, they had to recognize two molecules on the surface of the cell – not only the virus antigen, but also a molecule of the major histocompatibility complex (MHC). This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too. [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1996/illpres/experiment.html The Nobel Prize in Physiology or Medicine 1996 – Illustrated Presentation] ]

Doherty was born in Brisbane, Queensland, where he attended Indooroopilly State High School. He received his bachelor's degree in veterinary science in 1962 and his master's degree in veterinary science in 1966 from the University of Queensland. After obtaining his PhD in 1970 from the University of Edinburgh, Scotland, he returned to Australia to perform his Nobel Prize-winning research at the John Curtin School of Medical Research in Canberra. Doherty currently spends three months of the year conducting research at St. Jude Children's Research Hospital in Memphis, Tennessee, where he is a faculty member at the University of Tennessee Health Science Center. [http://www.utmem.edu/pathology/our_faculty.htm] For the other 9 months of the year he resides at the University of Melbourne, Victoria.

His semi-autobiographical book, "The Beginner's Guide to Winning the Nobel Prize", was published by The Miegunyah Press, an imprint of Melbourne University Publishing Ltd, Melbourne in 2005.

References

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authorlink=
year=|month=.
title=Peter Charles Doherty
journal=
volume=47
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pages=2–3
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*cite journal
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last=Doherty
first=P C
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year=1997|month=Dec.
title=The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cell mediated immunity in virus infections
journal=Scand. J. Immunol.
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pages=527–40
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*cite journal
quotes = yes
last=Zinkernagel
first=R M
authorlink=
year=1997|month=Nov.
title=The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cellular immune recognition and the biological role of major transplantation antigens
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year=1996|month=Dec.
title=The Nobel Prize in medicine 1996
journal=Scand. J. Immunol.
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pages=541–3
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doi=10.1046/j.1365-3083.1996.d01-361.x

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title=Nobel goes to T-cell pioneers whose work 'changed face of immunology'
journal=Nature
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External links

* [http://www.stjude.org/faculty/0,2512,407_2030_3859,00.html Webpage at St. Jude]
* [http://nobelprize.org/medicine/laureates/1996/doherty-autobio.html Nobel Biography]
* [http://www.twis.org/audio/2006/09/05/ Radio Interview] from This Week in Science 5 September 2005 broadcast
* [http://www.cosmosmagazine.com/node/719 "Winning a Nobel: easy as wrestling a pig"] , by Margaret Wertheim, "Cosmos" magazine, October 2006


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