- Arthur Kornberg
name = Arthur Kornberg
caption = Arthur Kornberg
birth_date = birth date|1918|3|3
New York City, United States
death_date = death date and age|2007|10|26|1918|3|3
Stanford, United States
National Institutes of Health
Washington University Stanford University
University of Rochester, New York University
Nobel Prize in Physiology or Medicine1959
Arthur Kornberg (
March 3, 1918– October 26, 2007) was an American biochemistwho won the Nobel Prize in Physiology or Medicine1959 for his discovery of "the mechanisms in the biological synthesis of deoxyribonucleic acid(DNA)" together with Dr. Severo Ochoaof New York University. He was also awarded the Paul-Lewis Laboratories Awardin Enzyme Chemistry from the American Chemical Societyin 1951, L.H.D. degree from Yeshiva Universityin 1962, as well as National Medal of Sciencein 1979.
His primary research interests were in
biochemistry, especially enzymechemistry, the synthesis of deoxyribonucleic acid(DNA) and studying the nucleic acids which control heredity in animals, plants, bacteria and viruses.
New York City, Arthur Kornberg was the son of Joseph and Lena Kornberg who emigrated to New York from Austrian Galicia (now part of Poland) in 1900 before they were married. His paternal grandfather had changed the family name from Queller (also spelled Kweller) to avoid the draft by taking on the identity of someone who had already completed military service. Joseph Kornberg married Lena Katz in 1904. He worked as a sewing machine operator in the sweat shops of the Lower East side of New York for almost 30 years, and when his health failed, opened a small hardware store in Brooklyn, where Arthur assisted customers at the age of nine. Joseph spoke at least six languages although he had no formal education.
Arthur Kornberg was educated first at Abraham Lincoln High School and then at
City Collegein New York City. He received at B. Sc. in 1937, followed by an M.D.at the University of Rochesterin 1941. Kornberg had a mildly elevated level of bilirubinin his blood— jaundicedue to an hereditarygenetic condition known as Gilbert's syndrome—and while at medical school he took a survey of fellow students to discover how common the condition was. The results were published in Kornberg's first research paper in 1942.
His internship was at
Strong Memorial Hospitalin Rochester, New York, between 1941-1942. After completing his medical training he joined the armed services as a Lieutenant in the United States Coast Guard, serving as a ship's doctor in 1942. Rolla Dyer, the Director of National Institutes of Health, had noticed his paper and invited him to join the research team at the Nutrition Laboratory of the NIH. From 1942 to 1945, Kornberg's work was the feeding of specialized diets to rats to discover new vitamins.
The feeding of rats was boring work, and Kornberg became fascinated by
enzymes. He transferred to Dr Severo Ochoa's laboratory at New York Universityin 1946, and took summer courses at Columbia Universityto fill out the gaps in his knowledge of organic and physical chemistry while learning the techniques of enzyme purification at work. He became Chief of the Enzyme and Metabolism Section at NIH from 1947-1953, working on understanding of ATP production from NAD and NADP. This led to his work on how DNA is built up from simpler molecules.
In 1953 he became Professor and Head of the Department of Microbiology,
Washington University, until 1959. Here he continued experimenting with the enzymes which created DNA. In 1956 he isolated the first DNA polymerizing enzyme, now known as DNA polymerase I[Nicole Kresge, Robert D. Simoni, Robert L. Hill (2005). Arthur Kornberg's Discovery of DNA Polymerase I. J. Biol. Chem. 280, 46. [http://www.jbc.org/cgi/content/full/280/49/e46 free fulltext] ] . This won him the Nobel prize in 1959.
In 1960 he received a
LL.D.again from City College, followed by a D.Sc.at the University of Rochesterin 1962. He became Professor and Executive Head of the Department of Biochemistry, Stanford University, Stanfordin 1959.
Kornberg's mother died of gas gangrene from a
sporeinfection after a routine gall bladderoperation in 1939. This started his lifelong fascination with spores, and he devoted some of his research efforts to understanding them while at Washington University. From 1962 to 1970, in the midst of his work on DNA synthesis, Kornberg devoted half his research effort to determining how DNA is stored in the spore, what replication mechanisms are included, and how the spore generates a new cell. This was an unfashionable but complex area of science, and although some progress was made, eventually Kornberg abandoned this research.
The Arthur Kornberg Medical Research Building at the
University of Rochester Medical Centerwas named in his honor in 1999.
Until his death Kornberg, still maintained an active research laboratory at Stanford, and regularly published peer reviewed scientific papers. For several years the focus of his research was the metabolism of
The "Kornberg school" of biochemistry refers to Arthur Kornberg's many graduate students and post-doctoral fellows, i.e., his intellectual children, and the trainees of his trainees, i.e., his intellectual grandchildren. Kornberg's intellectual children include
I. Robert Lehman, Randy Schekman, William T. Wicknerand Ken-ichi Arai.
November 21, 1943, Kornberg married Sylvy Ruth Levy, also a biochemist of note. She worked closely with Kornberg and contributed significantly to the discovery of DNA polymerase. The day after he was awarded the Nobel prize, she was quoted in a newspaper as saying "I was robbed".
Arthur and Sylvy Kornberg had three sons: Roger David Kornberg (1947) ,
Thomas B. Kornberg(1948), and Kenneth Andrew Kornberg (1950). Roger is Professor of Structural Biology at Stanford University, and the 2006 laureate of the Nobel Prize in Chemistry. Thomas discovered DNA polymeraseII and III in 1970 and is now a professor at the University of California, San Francisco. Kenneth is an architect specializing in the design of biomedical and biotechnology laboratories and buildings.
Arthur Kornberg was married three times. His first two wives predeceased him. Sylvy Kornberg died in 1986. Arthur Kornberg remarried in 1988 but his second wife, the former Charlene Walsh Levering, died in 1995. In December 1998 Arthur Kornberg married Carolyn Dixon. She survived him.
When he was in his eighties Arthur Kornberg continued to conduct research full time at Department of Biochemistry at Stanford. He died on
October 26, 2007at Stanford Hospital from respiratory failure.
* [http://www.pr-inside.com/arthur-kornberg-nobel-laureate-and-r269257.htm Arthur Kornberg, Nobel Laureate and Towering Biomedical Scientist, Dies at 89]
*"For the Love of Enzymes: The Odyssey of a Biochemist". Harvard University Press, Cambridge, MA, 1989, ISBN 0-674-30776-3
*"The Golden Helix: Inside Biotech Ventures". University Science Books, 2002, ISBN 1-891389-19-X
* Kornberg's [http://nobelprize.org/nobel_prizes/medicine/laureates/1959/kornberg-bio.html Nobel Foundation biography]
* Kornberg's Nobel Lecture [http://nobelprize.org/nobel_prizes/medicine/laureates/1959/kornberg-lecture.pdf The Biologic Synthesis of Deoxyribonucleic Acid] from Nobelprize.org website
* [http://cmgm.stanford.edu/biochem/faculty/kornberg.html Stanford University page]
* [http://www.gyaszhir.hu/book.php?id=21877 Arthur Kornberg - Condolence book (Hungarian)]
* [http://www.timesonline.co.uk/tol/comment/obituaries/article2820230.ece Obituary in "The Times", 7 November 2007]
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