Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2
Identifiers
Symbols	MCHR2; GPR145; GPRv17; MCH-2R; MCH-R2; MCH2; MCH2R; MCHR-2; SLT
External IDs	OMIM: 606111 HomoloGene: 50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity Cellular component • plasma membrane • plasma membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84539	n/a
Ensembl	ENSG00000152034	n/a
UniProt	Q969V1	n/a
RefSeq (mRNA)	NM_001040179.1	n/a
RefSeq (protein)	NP_001035269.1	n/a
Location (UCSC)	Chr 6: 100.37 – 100.44 Mb	n/a
PubMed search	[1]	n/a
This box: view · protein that in humans is encoded by the MCHR2 gene.[1][2][3] MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product. Clinical Significance Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[4] See also Melanin-concentrating hormone receptor References ^ "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539.  ^ Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.  ^ Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.  ^ Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ (June 2010). "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. doi:10.1055/s-0030-1249019. PMID 20340065.  External links "Melanin-Concentrating Hormone Receptors: MCH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999.  Further reading Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. doi:10.1073/pnas.121170598. PMC 34708. PMID 11404457. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34708.  An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMC 34710. PMID 11416225. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34710.  Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838.  Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.". Biochemistry 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.  Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.  Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.  Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals.". Genomics 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.  Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.". Proteins 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878.  Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.  This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Transmembrane receptor stubs G protein coupled receptors Wikimedia Foundation. 2010. 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