OGFR

Opioid growth factor receptor, also known as OGFR, is a human gene.cite web | title = Entrez Gene: OGFR opioid growth factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11054| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)] -enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported.cite web | title = Entrez Gene: OGFR opioid growth factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11054| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zagon IS, Verderame MF, McLaughlin PJ |title=The biology of the opioid growth factor receptor (OGFr). |journal=Brain Res. Brain Res. Rev. |volume=38 |issue= 3 |pages= 351–76 |year= 2002 |pmid= 11890982 |doi=
*cite journal | author=Zagon IS, Verderame MF, Allen SS, McLaughlin PJ |title=Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. |journal=Brain Res. |volume=856 |issue= 1-2 |pages= 75–83 |year= 2000 |pmid= 10677613 |doi=
*cite journal | author=Wu CJ, Yang XF, McLaughlin S, "et al." |title=Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia. |journal=J. Clin. Invest. |volume=106 |issue= 5 |pages= 705–14 |year= 2000 |pmid= 10974024 |doi=
*cite journal | author=Hattori A, Okumura K, Nagase T, "et al." |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357–66 |year= 2001 |pmid= 11214971 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zagon IS, Ruth TB, Leure-duPree AE, "et al." |title=Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. |journal=Brain Res. |volume=967 |issue= 1-2 |pages= 37–47 |year= 2003 |pmid= 12650964 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=McLaughlin PJ, Zagon IS |title=Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. |journal=Int. J. Oncol. |volume=28 |issue= 6 |pages= 1577–83 |year= 2006 |pmid= 16685459 |doi=
*cite journal | author=Zagon IS, McLaughlin PJ |title=Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 489–94 |year= 2006 |pmid= 16820893 |doi=
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS |title=Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. |journal=Int. J. Mol. Med. |volume=19 |issue= 3 |pages= 421–8 |year= 2007 |pmid= 17273790 |doi=

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