Frizzled homolog 9 (Drosophila), also known as FZD9, is a human gene.cite web | title = Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326| accessdate = ] FZD9 has also been designated as CD349 (cluster of differentiation 349).

section_title =
summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.cite web | title = Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326| accessdate = ]

ee also

* Frizzled


Further reading

citations =
*cite journal | author=Datta DV |title=Viral hepatitis (Chandigarh study). |journal=The Journal of the Association of Physicians of India |volume=25 |issue= 5 |pages= 325–30 |year= 1977 |pmid= 914765 |doi=
*cite journal | author=Wang YK, Samos CH, Peoples R, "et al." |title=A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. |journal=Hum. Mol. Genet. |volume=6 |issue= 3 |pages= 465–72 |year= 1997 |pmid= 9147651 |doi=
*cite journal | author=Finch PW, He X, Kelley MJ, "et al." |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=
*cite journal | author=Tanaka S, Akiyoshi T, Mori M, "et al." |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=
*cite journal | author=Wang YK, Spörle R, Paperna T, "et al." |title=Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. |journal=Genomics |volume=57 |issue= 2 |pages= 235–48 |year= 1999 |pmid= 10198163 |doi= 10.1006/geno.1999.5773
*cite journal | author=Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ |title=Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37479–86 |year= 2002 |pmid= 12138115 |doi= 10.1074/jbc.M205658200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Omoto S, Hayashi T, Kitahara K, "et al." |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270
*cite journal | author=Winn RA, Marek L, Han SY, "et al." |title=Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19625–34 |year= 2005 |pmid= 15705594 |doi= 10.1074/jbc.M409392200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Winn RA, Van Scoyk M, Hammond M, "et al." |title=Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26943–50 |year= 2006 |pmid= 16835228 |doi= 10.1074/jbc.M604145200

External links


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  • Frizzled — Pfam box Symbol = Frizzled Name = Frizzled/Smoothened family membrane region width = caption = Pfam= PF01534 InterPro= IPR000539 SMART= PROSITE = PDOC50038 SCOP = TCDB = OPM family= OPM protein= PDB=Frizzled is a family of G protein coupled… …   Wikipedia

  • Williams syndrome — Infobox Disease Name = Williams syndrome Caption = DiseasesDB = ICD10 = ICD10|Q|93|8|q|90 ICD9 = ICD9|758.9 ICDO = OMIM = 194050 MedlinePlus = 001116 eMedicineSubj = ped eMedicineTopic = 2439 MeshID = D018980 Williams syndrome (WS; also Williams… …   Wikipedia

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