Parathyroid hormone receptor

protein
Name = parathyroid hormone receptor 1
caption =


width =
HGNCid = 9608
Symbol = PTHR1
AltSymbols = PTHR
EntrezGene = 5745
OMIM = 168468
RefSeq = NM_000316
UniProt = Q03431
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 22
LocusSupplementaryData = -p21.1protein
Name = parathyroid hormone receptor 2
caption =


width =
HGNCid = 9609
Symbol = PTHR2
AltSymbols =
EntrezGene = 5746
OMIM = 601469
RefSeq = NM_005048
UniProt = P49190
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 33
LocusSupplementaryData = There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.cite journal | author = Jüppner H | title = Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors | journal = Curr. Opin. Nephrol. Hypertens. | volume = 3 | issue = 4 | pages = 371–8 | year = 1994 | pmid = 8076140 | doi = | issn = ]

* parathyroid hormone receptor 1 (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.cite journal | author = Mannstadt M, Jüppner H, Gardella TJ | title = Receptors for PTH and PTHrP: their biological importance and functional properties | journal = Am. J. Physiol. | volume = 277 | issue = 5 Pt 2 | pages = F665–75 | year = 1999 | pmid = 10564229 | doi = | issn = | url = http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 ] cite journal | author = Offermanns S, Iida-Klein A, Segre GV, Simon MI | title = G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells | journal = Mol. Endocrinol. | volume = 10 | issue = 5 | pages = 566–74 | year = 1996 | pmid = 8732687 | doi = 10.1210/me.10.5.566 | issn = ]

* parathyroid hormone receptor 2 (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.cite journal | author = Usdin TB, Bonner TI, Hoare SR | title = The parathyroid hormone 2 (PTH2) receptor | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 211–8 | year = 2002 | pmid = 12529938 | doi = | issn = ]

References

External links

*

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1327 IUPHAR GPCR Database - Parathyroid Hormone Receptors]