Histamine receptor


Histamine receptor

The histamine receptors are a class of G-protein coupled receptors with histamine as their endogenous ligand.cite journal | author = Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL | title = International Union of Pharmacology. XIII. Classification of histamine receptors | journal = Pharmacol. Rev. | volume = 49 | issue = 3 | pages = 253–78 | year = 1997 | pmid = 9311023 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/49/3/253 ]

There are four known histamine receptors:
*H1 receptor
*H2 receptor
*H3 receptor
*H4 receptor

Comparison

There are several splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in phosphoinositol hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.

References

External links

* [http://www.biotrend.com/download/5BT%20Histamine%20Review11_07.pdf Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007]
* [http://macromoleculeinsights.com/histaminerec.php The Histamine Receptor]
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1287 IUPHAR GPCR Database - Histamine Receptors]
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