Alpha-2C adrenergic receptor

The alpha-2C adrenergic receptor (α_2C adrenoreceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

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Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha_2A and alpha_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha_2C subtype modulated neurotransmission at lower levels of nerve activity.

Gene

This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.cite web | title = Entrez Gene: ADRA2C adrenergic, alpha-2C-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=152| accessdate = ]

ee also

*Adrenergic receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coupry I, Duzic E, Lanier SM |title=Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9852–7 |year= 1992 |pmid= 1349607 |doi=
*cite journal | author=Chhajlani V, Rangel N, Uhlén S, Wikberg JE |title=Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. |journal=FEBS Lett. |volume=280 |issue= 2 |pages= 241–4 |year= 1991 |pmid= 1849485 |doi=
*cite journal | author=Regan JW, Kobilka TS, Yang-Feng TL, "et al." |title=Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6301–5 |year= 1988 |pmid= 2842764 |doi=
*cite journal | author=Eason MG, Liggett SB |title=Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 70–5 |year= 1993 |pmid= 7688069 |doi=
*cite journal | author=Riess O, Thies U, Siedlaczck I, "et al." |title=Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16. |journal=Genomics |volume=19 |issue= 2 |pages= 298–302 |year= 1994 |pmid= 8188260 |doi= 10.1006/geno.1994.1061
*cite journal | author=Klein U, Ramirez MT, Kobilka BK, von Zastrow M |title=A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19099–102 |year= 1997 |pmid= 9235896 |doi=
*cite journal | author=Schaak S, Devedjian JC, Cayla C, "et al." |title=Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. |journal=Biochem. J. |volume=328 ( Pt 2) |issue= |pages= 431–8 |year= 1998 |pmid= 9371698 |doi=
*cite journal | author=DeGraff JL, Gagnon AW, Benovic JL, Orsini MJ |title=Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11253–9 |year= 1999 |pmid= 10196213 |doi=
*cite journal | author=Prezeau L, Richman JG, Edwards SW, Limbird LE |title=The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13462–9 |year= 1999 |pmid= 10224112 |doi=
*cite journal | author=Hein L, Altman JD, Kobilka BK |title=Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. |journal=Nature |volume=402 |issue= 6758 |pages= 181–4 |year= 2000 |pmid= 10647009 |doi= 10.1038/46040
*cite journal | author=Small KM, Forbes SL, Rahman FF, "et al." |title=A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23059–64 |year= 2000 |pmid= 10801795 |doi= 10.1074/jbc. M000796200
*cite journal | author=Comings DE, Gade-Andavolu R, Gonzalez N, "et al." |title=Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. |journal=Clin. Genet. |volume=58 |issue= 1 |pages= 31–40 |year= 2001 |pmid= 10945659 |doi=
*cite journal | author=Small KM, Wagoner LE, Levin AM, "et al." |title=Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. |journal=N. Engl. J. Med. |volume=347 |issue= 15 |pages= 1135–42 |year= 2002 |pmid= 12374873 |doi= 10.1056/NEJMoa020803
*cite journal | author=Chotani MA, Mitra S, Su BY, "et al." |title=Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=286 |issue= 1 |pages= H59–67 |year= 2004 |pmid= 12946937 |doi= 10.1152/ajpheart.00268.2003
*cite journal | author=Small KM, Mialet-Perez J, Seman CA, "et al." |title=Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 35 |pages= 13020–5 |year= 2004 |pmid= 15319474 |doi= 10.1073/pnas.0405074101
*cite journal | author=Chotani MA, Mitra S, Eid AH, "et al." |title=Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=288 |issue= 1 |pages= H69–76 |year= 2005 |pmid= 15345481 |doi= 10.1152/ajpheart.01223.2003
*cite journal | author=Belfer I, Buzas B, Hipp H, "et al." |title=Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. |journal=J. Hum. Genet. |volume=50 |issue= 1 |pages= 12–20 |year= 2005 |pmid= 15592690 |doi= 10.1007/s10038-004-0211-y
*cite journal | author=Neumeister A, Charney DS, Belfer I, "et al." |title=Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. |journal=Pharmacogenet. Genomics |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15861038 |doi=
*cite journal | author=Neumeister A, Drevets WC, Belfer I, "et al." |title=Effects of an alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. |journal=Neuropsychopharmacology |volume=31 |issue= 8 |pages= 1750–6 |year= 2006 |pmid= 16407897 |doi= 10.1038/sj.npp.1301010
*cite journal | author=Park JS, Zhang SY, Jo SH, "et al." |title=Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina. |journal=Am. Heart J. |volume=151 |issue= 4 |pages= 864–9 |year= 2006 |pmid= 16569551 |doi= 10.1016/j.ahj.2005.06.009

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