Frizzled homolog 7 (Drosophila), also known as FZD7, is a human gene.cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = ]

section_title =
summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = ]

ee also

* Frizzled


Further reading

citations =
*cite journal | author=Finch PW, He X, Kelley MJ, "et al." |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=
*cite journal | author=Tanaka S, Akiyoshi T, Mori M, "et al." |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=
*cite journal | author=Sagara N, Toda G, Hirai M, "et al." |title=Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 117–22 |year= 1998 |pmid= 9813155 |doi= 10.1006/bbrc.1998.9607
*cite journal | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817
*cite journal | author=Omoto S, Hayashi T, Kitahara K, "et al." |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vincan E, Darcy PK, Smyth MJ, "et al." |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Vincan E, Darcy PK, Farrelly CA, "et al." |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026
*cite journal | author=Struewing IT, Barnett CD, Zhang W, "et al." |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1. |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012

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Look at other dictionaries:

  • Frizzled — Pfam box Symbol = Frizzled Name = Frizzled/Smoothened family membrane region width = caption = Pfam= PF01534 InterPro= IPR000539 SMART= PROSITE = PDOC50038 SCOP = TCDB = OPM family= OPM protein= PDB=Frizzled is a family of G protein coupled… …   Wikipedia

  • DLG4 — Discs, large homolog 4 (Drosophila) PDB rendering based on 1be9 …   Wikipedia

  • Frizzled — Región de membrana de la familia Frizzled/Smoothened Estructura de cristalografía de rayos X del dominio rico en cisteínas de la proteína frizzled 8 (mfz8) de ratón.[1] …   Wikipedia Español

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