Opsin 5
Symbols OPN5; GPR136; PGR12; TMEM13
External IDs OMIM609042 MGI2662912 HomoloGene72341 IUPHAR: OPN5 GeneCards: OPN5 Gene
Species Human Mouse
Entrez 221391 353344
Ensembl ENSG00000124818 ENSMUSG00000043972
UniProt Q6U736 Q059L5
RefSeq (mRNA) NM_181744.3 NM_181753.4
RefSeq (protein) NP_001025222 NP_861418.2
Location (UCSC) Chr 6:
47.75 – 47.8 Mb
Chr 17:
42.69 – 42.75 Mb
PubMed search [1] [2]

Opsin-5 is a protein that in humans is encoded by the OPN5 gene.[1][2][3]

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

See also


  1. ^ Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ (Nov 2003). "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue". FEBS Lett 554 (3): 410–6. doi:10.1016/S0014-5793(03)01212-2. PMID 14623103. 
  2. ^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. 
  3. ^ a b "Entrez Gene: OPN5 opsin 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221391. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Metabolites and
signaling molecules
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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