Cosyntropin


Cosyntropin
Cosyntropin
Identifiers
CAS number 16960-16-0
PubChem 16129674
UNII 72YY86EA29
DrugBank DB01284
ChEMBL CHEMBL1201443
Jmol-3D images Image 1
Properties
Molecular formula C136H210N40O31S
Molar mass 2933.44 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cosyntropin (tradename Cortrosyn) is a synthetic derivative of ACTH that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders. Cosyntropin contains the first 24 (of a total 39) amino acids of ACTH but retains full function.[1]

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.

See also

References

  1. ^ Cortrosyn information

External links


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