CAS number 16960-16-0
PubChem 16129674
DrugBank DB01284
Jmol-3D images Image 1
Molecular formula C136H210N40O31S
Molar mass 2933.44 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cosyntropin (tradename Cortrosyn) is a synthetic derivative of ACTH that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders. Cosyntropin contains the first 24 (of a total 39) amino acids of ACTH but retains full function.[1]

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.

See also


  1. ^ Cortrosyn information

External links

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • cosyntropin — noun A synthetic derivative of ACTH that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders …   Wiktionary

  • cosyntropin — α1 24 or β1–24 Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the… …   Medical dictionary

  • ACTH stimulation test — Diagnostics OPS 301 code 1 797 The ACTH stimulation test (also called the cosyntropin test, tetracosactide test or Synacthen test) is a medical test usually ordered and interpreted by endocrinologists to assess the functioning of the …   Wikipedia

  • Adrenocorticotropic hormone — proopiomelanocortin (adrenocorticotropin/ beta lipotropin/ alpha melanocyte stimulating hormone/ beta melanocyte stimulating hormone/ beta endorphin) proopiomelanocortin derivatives POMC     …   Wikipedia

  • Oxytocin — Systematic (IUPAC) name 1 ({(4R,7S,10S …   Wikipedia

  • Desmopressin — Systematic (IUPAC) name (2S) N [(2R) 1 [(2 amino 2 oxoethyl)amino] 5 (diaminomethylideneamino) 1 oxopentan 2 yl] 1 [(4R,7S,10S,13S,16S) 7 (2 amino 2 oxoethyl) 10 (3 amino 3 oxopropyl) 16 [(4 hydroxyphenyl) …   Wikipedia

  • Congenital adrenal hyperplasia due to 21-hydroxylase deficiency — Classification and external resources Deficient 21 Hydroxylase can lead to accumulation of 17 Hydroxyprogesterone ICD …   Wikipedia

  • Conivaptan — Systematic (IUPAC) name N (4 (4,5 dihydro 2 methylimidazo[4,5 d][1]benzazepin 6(1H) yl)carbonyl)phenyl) (1,1 biphenyl) 2 carboxamide Clinical data …   Wikipedia

  • Felypressin — IUPAC name 1 [19 Amino 13,16 dibenzyl 10 (2 carbamoyl ethyl) 7 carbamoylmethyl 6,9,12,15,18 pentaoxo 1,2 dithia 5,8,11,14,17 pentaaz …   Wikipedia

  • Melanocortin receptor — Melanocortin receptors are members of the rhodopsin family of 7 transmembrane, G protein coupled receptors. There are five known members of the melanocortin receptor system[1] each with differing specificities for melanocortins:[2][3][4] …   Wikipedia