Bradykinin receptor

Bradykinin receptor

protein
Name = bradykinin receptor B1
caption =


width =
HGNCid = 1029
Symbol = BDKRB1
AltSymbols =
EntrezGene = 623
OMIM = 600337
RefSeq = NM_000710
UniProt = P46663
PDB =
ECnumber =
Chromosome = 14
Arm = q
Band = 32.1
LocusSupplementaryData = -32.2protein
Name = bradykinin receptor B2
caption =


width =
HGNCid = 1030
Symbol = BDKRB2
AltSymbols =
EntrezGene = 624
OMIM = 113503
RefSeq = NM_000623
UniProt = P30411
PDB =
ECnumber =
Chromosome = 14
Arm = q
Band = 32.1
LocusSupplementaryData = -32.2The bradykinin receptor is a receptor for bradykinin.

There are two Bradykinin receptors: the B1 receptor and the B2 receptor.cite journal | author = Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL | title = International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences | journal = Pharmacol. Rev. | volume = 57 | issue = 1 | pages = 27–77 | year = 2005 | pmid = 15734727 | doi = 10.1124/pr.57.1.2 | issn = ]

B2 receptor

The B2 receptor is a G protein-coupled receptor, coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 ]

Ictibant is a second generation B2 receptor antagonist which has undergone limited clinical trials in pain and inflammation.

Kallidin also signals through the B2 receptor.

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1330 IUPHAR GPCR Database - Bradykinin Receptor family]
*


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Bradykinin receptor B2 — Bradykinin receptor B2, also known as BDKRB2, is a bradykinin receptor, but also denotes the human gene encoding it.MechanismThe B2 receptor is a G protein coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase …   Wikipedia

  • Bradykinin receptor B1 — Bradykinin receptor B1, also known as BDKRB1, is a human gene.Bradykinin, a 9 amino acid peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G protein coupled receptors have… …   Wikipedia

  • Bradykinin — Chembox new ImageFile=Bradykinin.png ImageSize= IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=58 82 2 PubChem=6026 SMILES= MeSHName=Bradykinin Section2= Chembox Properties Formula=C50H73N15O11 MolarMass=1060.21 Appearance= Density=… …   Wikipedia

  • G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules …   Wikipedia

  • Relaxin/insulin-like family peptide receptor 4 — Relaxin/insulin like family peptide receptor 4, also known as RXFP4, is a human gene.cite web | title = Entrez Gene: RXFP4 relaxin/insulin like family peptide receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • FSH-receptor — Follicle stimulating hormone receptor PDB rendering based on 1xwd …   Wikipedia

  • kappa Opioid receptor — Opioid receptor, kappa 1 Rendering based on PDB 2A0D …   Wikipedia

  • Opioid receptor — Opioid receptors are a group of G protein coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are 40% identical to somatostatin… …   Wikipedia

  • Nociceptin receptor — Opiate receptor like 1 Identifiers Symbols OPRL1; KOR 3; MGC34578; NOCIR; OOR; ORL1 External IDs …   Wikipedia

  • Tachykinin receptor 1 — Rendering based on PDB 2KS9 …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”