Keratin 10


Keratin 10
Keratin 10
Identifiers
Symbols KRT10; BCIE; BIE; CK10; EHK; K10; KPP
External IDs OMIM148080 MGI96685 HomoloGene20125 GeneCards: KRT10 Gene
RNA expression pattern
PBB GE KRT10 213287 s at tn.png
PBB GE KRT10 207023 x at tn.png
PBB GE KRT10 210633 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3858 16661
Ensembl ENSG00000186395 ENSMUSG00000019761
UniProt P13645 P02535
RefSeq (mRNA) NM_000421.3 NM_010660.2
RefSeq (protein) NP_000412.3 NP_034790.2
Location (UCSC) Chr 17:
38.97 – 38.98 Mb
Chr 11:
99.25 – 99.25 Mb
PubMed search [1] [2]

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.[1][2][3] Keratin 10 is a type I keratin.

Contents

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.[3]

Interactions

Keratin 10 has been shown to interact with AKT1.[4]

See also

References

  1. ^ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol 91 (6): 572–8. doi:10.1111/1523-1747.ep12477087. PMID 2461420. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2064177. 
  3. ^ a b "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3858. 
  4. ^ Paramio, J M; Segrelles C, Ruiz S, Jorcano J L (Nov. 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. (United States) 21 (21): 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917. PMID 11585925. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99917. 

Further reading



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