Kinesin family member 21A, also known as KIF21A, is a human gene.cite web | title = Entrez Gene: KIF21A kinesin family member 21A| url =| accessdate = ]

section_title =
summary_text = KIF21A belongs to a family of plus end-directed kinesin (see MIM 600025) motor proteins. Neurons use kinesin and dynein (see MIM 600112) microtubule-dependent motor proteins to transport essential cellular components along axonal and dendritic microtubules. [supplied by OMIM] cite web | title = Entrez Gene: KIF21A kinesin family member 21A| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Yamada K, Hunter DG, Andrews C, Engle EC |title=A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw-winking phenomenon. |journal=Arch. Ophthalmol. |volume=123 |issue= 9 |pages= 1254–9 |year= 2005 |pmid= 16157808 |doi= 10.1001/archopht.123.9.1254
*cite journal | author=Engle EC, Kunkel LM, Specht LA, Beggs AH |title=Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12. |journal=Nat. Genet. |volume=7 |issue= 1 |pages= 69–73 |year= 1994 |pmid= 8075644 |doi= 10.1038/ng0594-69
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Marszalek JR, Weiner JA, Farlow SJ, "et al." |title=Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 469–79 |year= 1999 |pmid= 10225949 |doi=
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Nagase T, Kikuno R, Hattori A, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Magli A, de Berardinis T, D'Esposito F, Gagliardi V |title=Clinical and surgical data of affected members of a classic CFEOM I family. |journal=BMC ophthalmology |volume=3 |issue= |pages= 6 |year= 2004 |pmid= 12702216 |doi=
*cite journal | author=Yamada K, Andrews C, Chan WM, "et al." |title=Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). |journal=Nat. Genet. |volume=35 |issue= 4 |pages= 318–21 |year= 2004 |pmid= 14595441 |doi= 10.1038/ng1261
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yamada K, Chan WM, Andrews C, "et al." |title=Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 (CFEOM3). |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 7 |pages= 2218–23 |year= 2004 |pmid= 15223798 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tiab L, d'Allèves Manzi V, Borruat FX, "et al." |title=Mutation analysis of KIF21A in congenital fibrosis of the extraocular muscles (CFEOM) patients. |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 241–6 |year= 2005 |pmid= 15621876 |doi= 10.1080/13816810490902828
*cite journal | author=Ali M, Venkatesh C, Ragunath A, Kumar A |title=Mutation analysis of the KIF21A gene in an Indian family with CFEOM1: implication of CpG methylation for most frequent mutations. |journal=Ophthalmic Genet. |volume=25 |issue= 4 |pages= 247–55 |year= 2005 |pmid= 15621877 |doi= 10.1080/13816810490498198
*cite journal | author=Demer JL, Clark RA, Engle EC |title=Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 2 |pages= 530–9 |year= 2005 |pmid= 15671279 |doi= 10.1167/iovs.04-1125
*cite journal | author=Lin LK, Chien YH, Wu JY, "et al." |title=KIF21A gene c.2860C>T mutation in congenital fibrosis of extraocular muscles type 1 and 3. |journal=Mol. Vis. |volume=11 |issue= |pages= 245–8 |year= 2006 |pmid= 15827546 |doi=
*cite journal | author=Shimizu S, Okinaga A, Maruo T |title=Recurrent mutation of the KIF21A gene in Japanese patients with congenital fibrosis of the extraocular muscles. |journal=Jpn. J. Ophthalmol. |volume=49 |issue= 6 |pages= 443–7 |year= 2006 |pmid= 16365788 |doi= 10.1007/s10384-005-0243-7
*cite journal | author=Chan WM, Andrews C, Dragan L, "et al." |title=Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. |journal=BMC Genet. |volume=8 |issue= |pages= 26 |year= 2007 |pmid= 17511870 |doi= 10.1186/1471-2156-8-26

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Kinesin — Animation of kinesin walking on a microtubule The kinesin dimer attaches to, and mo …   Wikipedia

  • Microtubule — Space filling model of a microtubule segment derived from cryo electron microscopy. The protofilaments are seen running along the axis of the segment. The microtubule (+) end is towards the top of the image.[1] Microtubules are a component of the …   Wikipedia

  • Keratin — Not to be confused with kerogen, carotene, chitin, or creatine. Microscopy of keratin filaments inside cells. Keratin refers to a family of fibrous structural proteins. Keratin is the key structural material making up the outer layer of human… …   Wikipedia

  • Cytoskeleton — The eukaryotic cytoskeleton. Actin filaments are shown in red, microtubules in green, and the nuclei are in blue. The cytoskeleton (also CSK) is a cellular scaffolding or skeleton contained within a cell s cytoplasm and is made out of protein.… …   Wikipedia

  • Microfilament — Actin cytoskeleton of mouse embryo fibroblasts, stained with Fluorescein isothiocyanate phalloidin Microfilaments ( or actin filaments) are the thinnest filaments of the cytoskeleton, a structure found in the cytoplasm of all eukaryotic cells.… …   Wikipedia

  • Actin — G Actin (PDB code: 1j6z). ADP and the divalent cation are highlighted …   Wikipedia

  • Myosin — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosins comprise a family of ATP dependent motor proteins and are best known for their… …   Wikipedia

  • Lamin — Nuclear lamins, also known as Class V intermediate filaments, are fibrous proteins providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with membrane associated proteins to form the nuclear… …   Wikipedia

  • MreB — Procaryotic MreB (PDB code: 1jce) in cartoon representation. The fold of the protein is similar to its eukaryotic counterpart actin. MreB is a protein found in bacteria that has been identified as a homologue of actin, as indicated by… …   Wikipedia

  • Dynein — A dynein complex. Cytoplasmic dynein has two heavy chains with globular head …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.