MYO6


MYO6

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (C Elegans.)

PBB_Summary
section_title =
summary_text = Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins. [supplied by OMIM] cite web | title = Entrez Gene: MYO6 myosin VI| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4646| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Buss F, Luzio JP, Kendrick-Jones J |title=Myosin VI, a new force in clathrin mediated endocytosis. |journal=FEBS Lett. |volume=508 |issue= 3 |pages= 295–9 |year= 2001 |pmid= 11728438 |doi=
*cite journal | author=Hasson T |title=Myosin VI: two distinct roles in endocytosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 17 |pages= 3453–61 |year= 2004 |pmid= 12893809 |doi= 10.1242/jcs.00669
*cite journal | author=Avraham KB, Hasson T, Steel KP, "et al." |title=The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. |journal=Nat. Genet. |volume=11 |issue= 4 |pages= 369–75 |year= 1996 |pmid= 7493015 |doi= 10.1038/ng1295-369
*cite journal | author=Bement WM, Hasson T, Wirth JA, "et al." |title=Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6549–53 |year= 1994 |pmid= 8022818 |doi=
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Avraham KB, Hasson T, Sobe T, "et al." |title=Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1225–31 |year= 1997 |pmid= 9259267 |doi=
*cite journal | author=Buss F, Kendrick-Jones J, Lionne C, "et al." |title=The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. |journal=J. Cell Biol. |volume=143 |issue= 6 |pages= 1535–45 |year= 1999 |pmid= 9852149 |doi=
*cite journal | author=Wells AL, Lin AW, Chen LQ, "et al." |title=Myosin VI is an actin-based motor that moves backwards. |journal=Nature |volume=401 |issue= 6752 |pages= 505–8 |year= 1999 |pmid= 10519557 |doi= 10.1038/46835
*cite journal | author=Buss F, Arden SD, Lindsay M, "et al." |title=Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis. |journal=EMBO J. |volume=20 |issue= 14 |pages= 3676–84 |year= 2001 |pmid= 11447109 |doi= 10.1093/emboj/20.14.3676
*cite journal | author=Melchionda S, Ahituv N, Bisceglia L, "et al." |title=MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 635–40 |year= 2001 |pmid= 11468689 |doi=
*cite journal | author=Yoshimura M, Homma K, Saito J, "et al." |title=Dual regulation of mammalian myosin VI motor function. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39600–7 |year= 2001 |pmid= 11517222 |doi= 10.1074/jbc.M105080200
*cite journal | author=Rock RS, Rice SE, Wells AL, "et al." |title=Myosin VI is a processive motor with a large step size. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13655–9 |year= 2002 |pmid= 11707568 |doi= 10.1073/pnas.191512398
*cite journal | author=Inoue A, Sato O, Homma K, Ikebe M |title=DOC-2/DAB2 is the binding partner of myosin VI. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 2 |pages= 300–7 |year= 2002 |pmid= 11906161 |doi= 10.1006/bbrc.2002.6636
*cite journal | author=Morris SM, Arden SD, Roberts RC, "et al." |title=Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. |journal=Traffic |volume=3 |issue= 5 |pages= 331–41 |year= 2002 |pmid= 11967127 |doi=
*cite journal | author=Wu H, Nash JE, Zamorano P, Garner CC |title=Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30928–34 |year= 2002 |pmid= 12050163 |doi= 10.1074/jbc.M203735200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ahmed ZM, Morell RJ, Riazuddin S, "et al." |title=Mutations of MYO6 are associated with recessive deafness, DFNB37. |journal=Am. J. Hum. Genet. |volume=72 |issue= 5 |pages= 1315–22 |year= 2003 |pmid= 12687499 |doi=
*cite journal | author=Aschenbrenner L, Lee T, Hasson T |title=Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2728–43 |year= 2004 |pmid= 12857860 |doi= 10.1091/mbc.E02-11-0767

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