Keratin 17


Keratin 17

Keratin 17, also known as KRT17, is a human gene.cite web | title = Entrez Gene: KRT17 keratin 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3872| accessdate = ]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.cite web | title = Entrez Gene: KRT17 keratin 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3872| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Troyanovsky SM, Leube RE, Franke WW |title=Characterization of the human gene encoding cytokeratin 17 and its expression pattern |journal=Eur. J. Cell Biol. |volume=59 |issue= 1 |pages= 127–37 |year= 1993 |pmid= 1281771 |doi=
*cite journal | author=Flohr T, Buwitt U, Bonnekoh B, "et al." |title=Interferon-gamma regulates expression of a novel keratin class I gene |journal=Eur. J. Immunol. |volume=22 |issue= 4 |pages= 975–9 |year= 1992 |pmid= 1372562 |doi= 10.1002/eji.1830220415
*cite journal | author=Trask DK, Band V, Zajchowski DA, "et al." |title=Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 6 |pages= 2319–23 |year= 1990 |pmid= 1690428 |doi= 10.1073/pnas.87.6.2319
*cite journal | author=Kartasova T, Cornelissen BJ, Belt P, van de Putte P |title=Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes |journal=Nucleic Acids Res. |volume=15 |issue= 15 |pages= 5945–62 |year= 1987 |pmid= 2442723 |doi= 10.1093/nar/15.15.5945
*cite journal | author=Takahashi K, Folmer J, Coulombe PA |title=Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin |journal=J. Cell Biol. |volume=127 |issue= 2 |pages= 505–20 |year= 1994 |pmid= 7523421 |doi= 10.1083/jcb.127.2.505
*cite journal | author=Munro CS, Carter S, Bryce S, "et al." |title=A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21 |journal=J. Med. Genet. |volume=31 |issue= 9 |pages= 675–8 |year= 1995 |pmid= 7529318 |doi=
*cite journal | author=McLean WH, Rugg EL, Lunny DP, "et al." |title=Keratin 16 and keratin 17 mutations cause pachyonychia congenita |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 273–8 |year= 1995 |pmid= 7539673 |doi= 10.1038/ng0395-273
*cite journal | author=Leigh IM, Navsaria H, Purkis PE, "et al." |title=Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro |journal=Br. J. Dermatol. |volume=133 |issue= 4 |pages= 501–11 |year= 1995 |pmid= 7577575 |doi= 10.1111/j.1365-2133.1995.tb02696.x
*cite journal | author=Smith FJ, Corden LD, Rugg EL, "et al." |title=Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex |journal=J. Invest. Dermatol. |volume=108 |issue= 2 |pages= 220–3 |year= 1997 |pmid= 9008238 |doi= 10.1111/1523-1747.ep12335315
*cite journal | author=Covello SP, Smith FJ, Sillevis Smitt JH, "et al." |title=Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2 |journal=Br. J. Dermatol. |volume=139 |issue= 3 |pages= 475–80 |year= 1999 |pmid= 9767294 |doi=
*cite journal | author=McGowan KM, Coulombe PA |title=Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development |journal=J. Cell Biol. |volume=143 |issue= 2 |pages= 469–86 |year= 1998 |pmid= 9786956 |doi= 10.1083/jcb.143.2.469
*cite journal | author=Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG |title=Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture |journal=J. Cell. Sci. |volume=112 ( Pt 12) |issue= |pages= 1925–36 |year= 1999 |pmid= 10341211 |doi=
*cite journal | author=Celebi JT, Tanzi EL, Yao YJ, "et al." |title=Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2 |journal=J. Invest. Dermatol. |volume=113 |issue= 5 |pages= 848–50 |year= 1999 |pmid= 10571744 |doi= 10.1046/j.1523-1747.1999.00762.x
*cite journal | author=Smith FJ, Coleman CM, Bayoumy NM, "et al." |title=Novel keratin 17 mutations in pachyonychia congenita type 2 |journal=J. Invest. Dermatol. |volume=116 |issue= 5 |pages= 806–8 |year= 2001 |pmid= 11348474 |doi= 10.1046/j.0022-202x.2001.doc.x
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101
*cite journal | author=Hashiguchi T, Yotsumoto S, Shimada H, "et al." |title=A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2 |journal=J. Invest. Dermatol. |volume=118 |issue= 3 |pages= 545–7 |year= 2002 |pmid= 11874497 |doi= 10.1046/j.0022-202x.2001.01701.x
*cite journal | author=Terrinoni A, Smith FJ, Didona B, "et al." |title=Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita |journal=J. Invest. Dermatol. |volume=117 |issue= 6 |pages= 1391–6 |year= 2002 |pmid= 11886499 |doi= 10.1046/j.0022-202x.2001.01565.x
*cite journal | author=Scherl A, Couté Y, Déon C, "et al." |title=Functional proteomic analysis of human nucleolus |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271
*cite journal | author=van de Rijn M, Perou CM, Tibshirani R, "et al." |title=Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome |journal=Am. J. Pathol. |volume=161 |issue= 6 |pages= 1991–6 |year= 2003 |pmid= 12466114 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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