Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the z-line membrane, in muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.

The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.

Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis.


* ACTN1, Gene|ACTN2, ACTN3, Gene|ACTN4

ee also

* actin

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Look at other dictionaries:

  • actinin — /ak teuh nin/, n. Biochem. a contractile protein of muscle. [1970 75; ACTIN + IN2] * * * …   Universalium

  • actinin — noun Any of several microfilament proteins that have a function in the attachment of actin fibres in muscle cells …   Wiktionary

  • actinin — /ak teuh nin/, n. Biochem. a contractile protein of muscle. [1970 75; ACTIN + IN2] …   Useful english dictionary

  • Actinin, alpha 2 — Actinin, alpha 2, also known as ACTN2, is a human gene.cite web | title = Entrez Gene: ACTN2 actinin, alpha 2| url = Cmd=ShowDetailView TermToSearch=88| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Actinin alpha 4 — Actinin, alpha 4, also known as ACTN4, is a human gene.cite web | title = Entrez Gene: ACTN4 actinin, alpha 4| url = Cmd=ShowDetailView TermToSearch=81| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Alpha-Actinin 3 — Masse/Länge Primärstruktur 901 Aminosäuren …   Deutsch Wikipedia

  • alpha-actinin — (= a actinin) A protein of 100 kD normally found as a dimer and that may link actin filaments end to end with opposite polarity. Originally described in the Z disc, now known to occur in stress fibres and at focal adhesions. Non muscle isoform… …   Dictionary of molecular biology

  • beta-actinin — (= b actinin) See capZ …   Dictionary of molecular biology

  • α-actinin — An F actin binding protein in vertebrate cells that cross links actin filaments into regular parallel arrays. It is found in both the Z line and the I band …   Medical dictionary

  • α-actinin — α ac·tin·in (akґtə nin) a 100 kD protein occurring as a dimer and found in muscle, fibroblasts, and epithelial cells; it binds actin filaments to one another and to cell membranes and in the Z band holds the actin fibers in a lattice… …   Medical dictionary

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