Keratin 86, also known as KRT86, is a human gene.cite web | title = Entrez Gene: KRT86 keratin 86| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.cite web | title = Entrez Gene: KRT86 keratin 86| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Langbein L, Schweizer J |title=Keratins of the human hair follicle. |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 1–78 |year= 2005 |pmid= 15797458 |doi= 10.1016/S0074-7696(05)43001-6
*cite journal | author=Rogers MA, Nischt R, Korge B, "et al." |title=Sequence data and chromosomal localization of human type I and type II hair keratin genes. |journal=Exp. Cell Res. |volume=220 |issue= 2 |pages= 357–62 |year= 1995 |pmid= 7556444 |doi= 10.1006/excr.1995.1326
*cite journal | author=Rogers MA, Langbein L, Praetzel S, "et al." |title=Sequences and differential expression of three novel human type-II hair keratins. |journal=Differentiation |volume=61 |issue= 3 |pages= 187–94 |year= 1997 |pmid= 9084137 |doi=
*cite journal | author=Winter H, Rogers MA, Langbein L, "et al." |title=Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. |journal=Nat. Genet. |volume=16 |issue= 4 |pages= 372–4 |year= 1997 |pmid= 9241275 |doi= 10.1038/ng0897-372
*cite journal | author=Winter H, Rogers MA, Gebhardt M, "et al." |title=A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 165–9 |year= 1998 |pmid= 9402962 |doi=
*cite journal | author=Bowden PE, Hainey SD, Parker G, "et al." |title=Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 158–64 |year= 1998 |pmid= 9457912 |doi= 10.1046/j.1523-1747.1998.00097.x
*cite journal | author=Winter H, Clark RD, Tarras-Wahlberg C, "et al." |title=Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6. |journal=J. Invest. Dermatol. |volume=113 |issue= 2 |pages= 263–6 |year= 1999 |pmid= 10469314 |doi= 10.1046/j.1523-1747.1999.00685.x
*cite journal | author=Korge BP, Hamm H, Jury CS, "et al." |title=Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype. |journal=J. Invest. Dermatol. |volume=113 |issue= 4 |pages= 607–12 |year= 1999 |pmid= 10504448 |doi= 10.1046/j.1523-1747.1999.00722.x
*cite journal | author=Pearce EG, Smith SK, Lanigan SW, Bowden PE |title=Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix. |journal=J. Invest. Dermatol. |volume=113 |issue= 6 |pages= 1123–7 |year= 2000 |pmid= 10594761 |doi= 10.1046/j.1523-1747.1999.00777.x
*cite journal | author=Rogers MA, Winter H, Langbein L, "et al." |title=Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. |journal=J. Invest. Dermatol. |volume=114 |issue= 3 |pages= 464–72 |year= 2000 |pmid= 10692104 |doi= 10.1046/j.1523-1747.2000.00910.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schweizer J, Bowden PE, Coulombe PA, "et al." |title=New consensus nomenclature for mammalian keratins. |journal=J. Cell Biol. |volume=174 |issue= 2 |pages= 169–74 |year= 2006 |pmid= 16831889 |doi= 10.1083/jcb.200603161

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Monilethrix — Classification and external resources ICD 10 Q84.1 (ILDS Q84.140) ICD 9 757.4 …   Wikipedia

  • Keratin — Not to be confused with kerogen, carotene, chitin, or creatine. Microscopy of keratin filaments inside cells. Keratin refers to a family of fibrous structural proteins. Keratin is the key structural material making up the outer layer of human… …   Wikipedia

  • Marfan syndrome — Marfan redirects here. For the person after whom the syndrome is named, see Antoine Marfan. Marfan syndrome Classification and external resources Micrograph demonstrating myxomatous degeneration of the aorti …   Wikipedia

  • Limb-girdle muscular dystrophy — Classification and external resources ICD 10 G71.0 ICD 9 359.1 …   Wikipedia

  • Hereditary spherocytosis — This article is about aspects of spherocytosis specific to the hereditary form of the disorder. For details that apply generally to this variant as well as others, see Spherocytosis. Hereditary spherocytosis Classification and external resources… …   Wikipedia

  • Arrhythmogenic right ventricular dysplasia — Classification and external resources Photomicrograph of an ARVC heart. ICD 10 I …   Wikipedia

  • Hypertrophic cardiomyopathy — Classification and external resources ICD 10 I42.1–I42.2 ICD 9 …   Wikipedia

  • Dilated cardiomyopathy — Classification and external resources ICD 10 I42.0 ICD 9 425.4 …   Wikipedia

  • Epidermolytic hyperkeratosis — Classification and external resources ICD 10 Q80.3 OMIM 113800 Diseases …   Wikipedia

  • Alexander disease — Classification and external resources ICD 9 331.89 OMIM 203450 MeSH …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.