KRT86


KRT86

Keratin 86, also known as KRT86, is a human gene.cite web | title = Entrez Gene: KRT86 keratin 86| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3892| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.cite web | title = Entrez Gene: KRT86 keratin 86| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3892| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Langbein L, Schweizer J |title=Keratins of the human hair follicle. |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 1–78 |year= 2005 |pmid= 15797458 |doi= 10.1016/S0074-7696(05)43001-6
*cite journal | author=Rogers MA, Nischt R, Korge B, "et al." |title=Sequence data and chromosomal localization of human type I and type II hair keratin genes. |journal=Exp. Cell Res. |volume=220 |issue= 2 |pages= 357–62 |year= 1995 |pmid= 7556444 |doi= 10.1006/excr.1995.1326
*cite journal | author=Rogers MA, Langbein L, Praetzel S, "et al." |title=Sequences and differential expression of three novel human type-II hair keratins. |journal=Differentiation |volume=61 |issue= 3 |pages= 187–94 |year= 1997 |pmid= 9084137 |doi=
*cite journal | author=Winter H, Rogers MA, Langbein L, "et al." |title=Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. |journal=Nat. Genet. |volume=16 |issue= 4 |pages= 372–4 |year= 1997 |pmid= 9241275 |doi= 10.1038/ng0897-372
*cite journal | author=Winter H, Rogers MA, Gebhardt M, "et al." |title=A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 165–9 |year= 1998 |pmid= 9402962 |doi=
*cite journal | author=Bowden PE, Hainey SD, Parker G, "et al." |title=Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 158–64 |year= 1998 |pmid= 9457912 |doi= 10.1046/j.1523-1747.1998.00097.x
*cite journal | author=Winter H, Clark RD, Tarras-Wahlberg C, "et al." |title=Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6. |journal=J. Invest. Dermatol. |volume=113 |issue= 2 |pages= 263–6 |year= 1999 |pmid= 10469314 |doi= 10.1046/j.1523-1747.1999.00685.x
*cite journal | author=Korge BP, Hamm H, Jury CS, "et al." |title=Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype. |journal=J. Invest. Dermatol. |volume=113 |issue= 4 |pages= 607–12 |year= 1999 |pmid= 10504448 |doi= 10.1046/j.1523-1747.1999.00722.x
*cite journal | author=Pearce EG, Smith SK, Lanigan SW, Bowden PE |title=Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix. |journal=J. Invest. Dermatol. |volume=113 |issue= 6 |pages= 1123–7 |year= 2000 |pmid= 10594761 |doi= 10.1046/j.1523-1747.1999.00777.x
*cite journal | author=Rogers MA, Winter H, Langbein L, "et al." |title=Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. |journal=J. Invest. Dermatol. |volume=114 |issue= 3 |pages= 464–72 |year= 2000 |pmid= 10692104 |doi= 10.1046/j.1523-1747.2000.00910.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schweizer J, Bowden PE, Coulombe PA, "et al." |title=New consensus nomenclature for mammalian keratins. |journal=J. Cell Biol. |volume=174 |issue= 2 |pages= 169–74 |year= 2006 |pmid= 16831889 |doi= 10.1083/jcb.200603161

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