TUBA4A


TUBA4A

Tubulin, alpha 4a, also known as TUBA4A, is a human gene.

PBB_Summary
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summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. [cite web | title = Entrez Gene: TUBA4A tubulin, alpha 4a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7277| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523–7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L |doilabel=10.1002/(SICI)1521-1878(199807)20:7523::AID-BIES13.0.CO;2-L
*cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537–42 |year= 2001 |pmid= 11121746 |doi=
*cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49–54 |year= 2001 |pmid= 11163133 |doi=
*cite journal | author=Kirsch J, Langosch D, Prior P, "et al." |title=The 93-kDa glycine receptor-associated protein binds to tubulin. |journal=J. Biol. Chem. |volume=266 |issue= 33 |pages= 22242–5 |year= 1991 |pmid= 1657993 |doi=
*cite journal | author=Dobner PR, Kislauskis E, Wentworth BM, Villa-Komaroff L |title=Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. |journal=Nucleic Acids Res. |volume=15 |issue= 1 |pages= 199–218 |year= 1987 |pmid= 3029670 |doi=
*cite journal | author=Villasante A, Wang D, Dobner P, "et al." |title=Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. |journal=Mol. Cell. Biol. |volume=6 |issue= 7 |pages= 2409–19 |year= 1987 |pmid= 3785200 |doi=
*cite journal | author=Hall JL, Cowan NJ |title=Structural features and restricted expression of a human alpha-tubulin gene. |journal=Nucleic Acids Res. |volume=13 |issue= 1 |pages= 207–23 |year= 1985 |pmid= 3839072 |doi=
*cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, "et al." |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi=
*cite journal | author=Yamaguchi N, Fukuda MN |title=Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 12170–6 |year= 1995 |pmid= 7744867 |doi=
*cite journal | author=Waterman-Storer CM, Karki S, Holzbaur EL |title=The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1634–8 |year= 1995 |pmid= 7878030 |doi=
*cite journal | author=Lu Q, Luduena RF |title=In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2041–7 |year= 1994 |pmid= 8294455 |doi=
*cite journal | author=Paschal BM, Holzbaur EL, Pfister KK, "et al." |title=Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin. |journal=J. Biol. Chem. |volume=268 |issue= 20 |pages= 15318–23 |year= 1993 |pmid= 8325901 |doi=
*cite journal | author=Huby RD, Carlile GW, Ley SC |title=Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30241–4 |year= 1996 |pmid= 8530437 |doi=
*cite journal | author=Marie-Cardine A, Kirchgessner H, Eckerskorn C, "et al." |title=Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase. |journal=Eur. J. Immunol. |volume=25 |issue= 12 |pages= 3290–7 |year= 1996 |pmid= 8566014 |doi=
*cite journal | author=Peters JD, Furlong MT, Asai DJ, "et al." |title=Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 4755–62 |year= 1996 |pmid= 8617742 |doi=
*cite journal | author=Best A, Ahmed S, Kozma R, Lim L |title=The Ras-related GTPase Rac1 binds tubulin. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3756–62 |year= 1996 |pmid= 8631991 |doi=
*cite journal | author=Tokito MK, Howland DS, Lee VM, Holzbaur EL |title=Functionally distinct isoforms of dynactin are expressed in human neurons. |journal=Mol. Biol. Cell |volume=7 |issue= 8 |pages= 1167–80 |year= 1997 |pmid= 8856662 |doi=
*cite journal | author=Tian G, Lewis SA, Feierbach B, "et al." |title=Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. |journal=J. Cell Biol. |volume=138 |issue= 4 |pages= 821–32 |year= 1997 |pmid= 9265649 |doi=
*cite journal | author=Vaillant AR, Müller R, Langkopf A, Brown DL |title=Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13973–81 |year= 1998 |pmid= 9593747 |doi=

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