MYO18B


MYO18B

Myosin XVIIIB, also known as MYO18B, is a human gene.cite web | title = Entrez Gene: MYO18B myosin XVIIIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84700| accessdate = ]

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summary_text = The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.cite web | title = Entrez Gene: MYO18B myosin XVIIIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84700| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Yokota J, Nishioka M, Tani M, Kohno T |title=Genetic alterations responsible for metastatic phenotypes of lung cancer cells. |journal=Clin. Exp. Metastasis |volume=20 |issue= 3 |pages= 189–93 |year= 2003 |pmid= 12741677 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Nishioka M, Kohno T, Tani M, "et al." |title=MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12269–74 |year= 2002 |pmid= 12209013 |doi= 10.1073/pnas.192445899
*cite journal | author=Salamon M, Millino C, Raffaello A, "et al." |title=Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. |journal=J. Mol. Biol. |volume=326 |issue= 1 |pages= 137–49 |year= 2003 |pmid= 12547197 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yanaihara N, Nishioka M, Kohno T, "et al." |title=Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. |journal=Int. J. Cancer |volume=112 |issue= 1 |pages= 150–4 |year= 2004 |pmid= 15305387 |doi= 10.1002/ijc.20339
*cite journal | author=Inoue T, Kon T, Ajima R, "et al." |title=MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 3 |pages= 829–34 |year= 2006 |pmid= 16499872 |doi= 10.1016/j.bbrc.2006.02.025
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Edakuni N, Ikuta K, Yano S, "et al." |title=Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice. |journal=Oncol. Res. |volume=16 |issue= 5 |pages= 235–43 |year= 2007 |pmid= 17294804 |doi=

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