Anileridine


Anileridine
Anileridine
Systematic (IUPAC) name
Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat.  ?
Legal status -only (CA) Schedule II (US)
Routes Tablets, injection
Pharmacokinetic data
Protein binding > 95%
Metabolism Hepatic
Identifiers
CAS number 144-14-9 YesY
ATC code N01AH05
PubChem CID 8944
DrugBank APRD00741
ChemSpider 8600 YesY
UNII 71Q1A3O279 YesY
KEGG D02941 YesY
ChEBI CHEBI:61203 YesY
ChEMBL CHEMBL1201347 N
Chemical data
Formula C22H28N2O2 
Mol. mass 352.47 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 83 °C (181 °F)
 N(what is this?)  (verify)

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s[1]. It differs from meperidine (Demerol) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.[2]

Administration

As tablets or injection.[3]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.

References