IUPAC_name = (8"E")-8- [hydroxy-(pyridin-2-ylamino)methylidene] -
9-methyl-10,10-dioxo-10λ6-thia-9-azabicyclo [4.4.0]

width = 250
CAS_number = 36322-90-4
ATC_prefix = M01
ATC_suffix = AC01
ATC_supplemental = ATC|M02|AA07, ATC|S01|BC06
PubChem = 5280452
DrugBank = APRD01187
C = 15 | H = 13 | N = 3 | O = 4 | S = 1
molecular_weight = 331.348 g/mol
bioavailability =
protein_bound =
metabolism = 4 to 10% renal
elimination_half-life = 30 to 86 hours
pregnancy_category = C, D if used in the third trimester or near delivery
legal_status = POM
routes_of_administration = PO
excretion = 4 to 10% renal

Piroxicam is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is manufacturerd by Pfizer under the tradename Feldene, and is available in the UK and USA.

It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

Other brand names for Piroxicam include "Brexidol", "Brexin", "Erazon", "Felden", "Feldoral", "Hotemin", "Pirox von ct", "Proponol", "Reumador", "Tracam", "Veral", and "Vurdon".

Mechanism of action

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes enterohepatic circulation.

Adverse effects

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects. [cite web | author=New Zealand Medicines and Medical Devices Safety Authority | title=Candyl Medicines datasheet | url=http://www.medsafe.govt.nz | accessdate=2006-09-10]

Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.Fact|date=July 2007


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Look at other dictionaries:

  • Piroxicam — Saltar a navegación, búsqueda Piroxicam Aviso …   Wikipedia Español

  • Piroxicam — Général Nom IUPAC (8E) 8 [hydroxy (pyridin 2 ylamino)methylidene] 9 methyl 10,10 dioxo 10λ6 thia 9 azabicyclo[4.4.0] deca 1,3,5 trien 7 one …   Wikipédia en Français

  • Piroxicam — Strukturformel Allgemeines Freiname Piroxicam Andere Namen …   Deutsch Wikipedia

  • Piroxicam — ПИРОКСИКАМ ( Piroxicam ). 4 Окси 2 метил 3 (N пиридил 2)карбоксамидо 2Н 1,2 бензотиазин 1,1 диокисью Синонимы: Пирокс, Роксикам, Толдин, Algitrat, Androxicam, Calmapir, Erason, Feldene, Pirox, Piroxiflam, Pronaxen, Toldin и др. Желтоватый… …   Словарь медицинских препаратов

  • piroxicam — /puy rok si kam /, n. Pharm. a white crystalline solid substance, C15H13N3O4S, used in the symptomatic treatment of osteoarthritis and rheumatoid arthritis and other musculoskeletal disorders. [by rearrangement and alter. of parts of its chemical …   Universalium

  • piroxicam — noun A certain oxicam drug …   Wiktionary

  • Piroxicam — Pi|r|o|xi|cam [Kurzw. aus ↑ Pyridin u. ↑ Oxicam], das; s: internat. Freiname für ein nichtsteroidales Antirheumatikum …   Universal-Lexikon

  • piroxicam — pi·rox·i·cam pi räk sə .kam n a nonsteroidal anti inflammatory drug C15H13N3O4S used in the treatment of rheumatic diseases (as osteoarthritis) * * * n. a nonsteroidal anti inflammatory drug (see NSAID) used to relieve pain and stiffness in… …   Medical dictionary

  • piroxicam — n. a nonsteroidal anti inflammatory drug (see NSAID) used to relieve pain and stiffness in osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. It is administered by mouth, injection, or topically; side effects include… …   The new mediacal dictionary

  • piroxicam — noun a nonsteroidal anti inflammatory drug (trade name Feldene) used to treat arthritis and other inflammatory conditions • Syn: ↑Feldene • Usage Domain: ↑trade name (for: ↑Feldene) • Hypernyms: ↑nonste …   Useful english dictionary

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