Flurbiprofen


Flurbiprofen
Flurbiprofen
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Trade names Ansaid, Ocufen
AHFS/Drugs.com monograph
MedlinePlus a687005
Pregnancy cat. C (U.S.), B2 (Au)
Legal status POM
Routes Oral
Pharmacokinetic data
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half-life 4.7-5.7 hours
Excretion Renal
Identifiers
CAS number 5104-49-4
ATC code M01AE09 , M02AA19, R02AX01, S01BC04
PubChem CID 3394
DrugBank APRD00753
ChemSpider 3277 YesY
UNII 5GRO578KLP YesY
KEGG D00330 YesY
ChEBI CHEBI:5130 YesY
ChEMBL CHEMBL563 YesY
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
Chemical data
Formula C15H13FO2 
Mol. mass 244.261 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 117 °C (243 °F)
 YesY(what is this?)  (verify)

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.[1] It is known by the following tradenames: Urbifen marketed by General Pharmaceuticals, Ansaid, marketed by Pfizer, Flurwood by W.Woodward and Froben, by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of racemic flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

References