IUPAC_name = propyl 2- [4-(diethylcarbamoylmethoxy)-3-methoxy-
width = 250
C = 18 | H = 27 | N = 1 | O = 5
molecular_weight = 337.411 g/mol
Propanidid is an ultra short-acting
phenylacetate general anesthetic. It was originally introduced by Bayerbut anaphylactic reactions caused it to be withdrawn shortly afterwards.
Cremophor ELhas been shown to cause anaphylactic reactions in humans in several cases (both when given intraveneosly and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to Propanidid (and
Althesin) were due to the drugs themselves [cite web | title=A new Steroid Anaesthetic - Althesin | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1645602&blobtype=pdf | format=pdf| publisher=PubMed | accessdate=2007-01-07 See page 1/49] . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.
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