Propanidid


Propanidid

Drugbox
IUPAC_name = propyl 2- [4-(diethylcarbamoylmethoxy)-3-methoxy-
phenyl] acetate



width = 250
CAS_number=1421-14-3
ATC_prefix=N01
ATC_suffix=AX04
ATC_supplemental=
PubChem=15004
DrugBank=
C = 18 | H = 27 | N = 1 | O = 5
molecular_weight = 337.411 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer but anaphylactic reactions caused it to be withdrawn shortly afterwards.

Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intraveneosly and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.

It has been argued that the toxic effects or reactions to Propanidid (and Althesin) were due to the drugs themselves [cite web | title=A new Steroid Anaesthetic - Althesin | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1645602&blobtype=pdf | format=pdf| publisher=PubMed | accessdate=2007-01-07 See page 1/49] . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.

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