Alfentanil


Alfentanil

drugbox



IUPAC_name = "N"- [1- [2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl] -
4-(methoxymethyl)-4-piperidyl] -"N"-phenyl-propanamide
CAS_number = 71195-58-9
ATC_prefix = N01
ATC_suffix = AH02
PubChem = 51263
smiles = CCC(=O)N(c1ccccc1)C3(COC)CCN(CCn2nnn(CC)c2=O)CC3
DrugBank = APRD00726
C = 21 | H = 32 | N = 6 | O = 3
molecular_weight = 416.517 g/mol
melting_point = 140.8
bioavailability = 100%
protein_bound = 92%
metabolism = Hepatic
elimination_half-life = 90–111 minutes
legal_US = Schedule II
legal_UK = Class A
routes_of_administration = Intravenous

Alfentanil (trade name Alfenta) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/4 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl. [ [http://www.google.com/patents?id=msJ_AAAAEBAJ&dq=7208604 Jacob Mathew, J. Kendall Killgore. Methods for the synthesis of alfentanil, sufentanil, and remifentanil. US Patent 7,208,604] ] It is an OP3 mu-agonist.

While alfentanil tends to cause less cardiovascular complications than other similar drugs such as fentanyl and remifentanil it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.

Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website. [http://www.deadiversion.usdoj.gov/schedules/listby_sched/sched2.htm From DEA website, accessed 23 Jan 2007] ]

Alfentanil was discovered at Janssen Pharmaceutica in 1976.

References

External links

* [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601130.html some more info]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Alfentanil — Général Nom IUPAC N [1 [2 (4 éthyl 5 oxo 1,4 dihydrotétrazol 1 yl)éthyl] 4 (méthoxyméthyl) 4 pipéridyl] N phényl propanamide …   Wikipédia en Français

  • Alfentanil — Strukturformel Allgemeines Freiname Alfentanil Andere Namen …   Deutsch Wikipedia

  • alfentanil — noun A particular narcotic anesthetic …   Wiktionary

  • alfentanil — n. an opioid analgesic drug used mainly for pain relief during surgery (see opiate). It is administered by injection, usually at induction of anaesthesia. Trade names: Rapifen …   The new mediacal dictionary

  • alfentanil hydrochloride — A very potent, short acting narcotic agonist analgesic used as an anesthetic or as an adjunct in the maintenance of general anesthesia. * * * a narcotic analgesic drug used to relieve severe pain. It is administered by injection.… …   Medical dictionary

  • Альфентанил Гидрохлорид (Alfentanil Hydrochloride) — наркотический лекарственный препарат, анальгетик, применяется для уменьшения сильной боли. Назначается в инъекциях. Торговое название: ралифен (Rapifen). Источник: Медицинский словарь …   Медицинские термины

  • 71195-58-9 — Alfentanil Alfentanil Général Nom IUPAC N [1 [2 (4 éthyl 5 oxo 1,4 dihydrotétrazol 1 yl)éthyl] 4 (méthoxyméthyl) 4 pipéridyl] N phényl propanamide …   Wikipédia en Français

  • C21H32N6O3 — Alfentanil Alfentanil Général Nom IUPAC N [1 [2 (4 éthyl 5 oxo 1,4 dihydrotétrazol 1 yl)éthyl] 4 (méthoxyméthyl) 4 pipéridyl] N phényl propanamide …   Wikipédia en Français

  • АЛЬФЕНТАНИЛ ГИДРОХЛОРИД — (alfentanil hydrochloride) наркотический лекарственный препарат, анальгетик, применяется для уменьшения сильной боли. Назначается в инъекциях. Торговое название: ралифен (Rapifen) …   Толковый словарь по медицине

  • Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.