Structure of a typical neuron Myelin sheath
Myelin is a dielectric (electrically insulating) material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth of a type of glial cell. The production of the myelin sheath is called myelination. In humans, the production of myelin begins in the fourteenth week of fetal development, although little myelin exists in the brain at the time of birth. During infancy, myelination occurs quickly and continues through the adolescent stages of life.
Schwann cells supply the myelin for peripheral neurons, whereas oligodendrocytes, specifically of the interfascicular type, myelinate the axons of the central nervous system. Myelin is considered a defining characteristic of the (gnathostome) vertebrates, but myelin-like sheaths have also arisen by parallel evolution in some invertebrates, although they are quite different from vertebrate myelin at the molecular level. Myelin was discovered in 1854 by Rudolf Virchow.
Composition of myelin
Myelin may be made by different cell types varies in chemical composition and configuration, but performs the same insulating function. Myelinated axons are white in appearance, hence the "white matter" of the brain.
Myelin is about 40 % water; the dry mass of myelin is about 70 - 85 % lipids and about 15 - 30 % proteins. Some of the proteins that make up myelin are myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The primary lipid of myelin is a glycolipid called galactocerebroside. The intertwining hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath.
Function of myelin layer
The main purpose of a myelin layer (or sheath) is to increase the speed at which impulses propagate along the myelinated fiber. Along unmyelinated fibers, impulses move continuously as waves, but, in myelinated fibers, they hop or "propagate by saltation." Myelin increases electrical resistance across the cell membrane by a factor of 5,000 and decreases capacitance by a factor of 50. Thus, myelination helps prevent the electrical current from leaving the axon.
When a peripheral fiber is severed, the myelin sheath provides a track along which regrowth can occur. Unfortunately, the myelin layer does not ensure a perfect regeneration of the nerve fiber. Some regenerated nerve fibers do not find the correct muscle fibers and some damaged motor neurons of the PNS die without re-growth. Damage to the myelin sheath and nerve fiber is often associated with increased functional insufficiency.
Unmyelinated fibers and myelinated axons of the mammalian central nervous system do not regenerate.This is mainly because the central nervous system is enclosed in bone, thus suffering less trauma than the peripheral nervous system.
Some studies reveal that optic nerve fibers can be regenerated in postnatal rats. This optic nerve regeneration depends upon two conditions: axonal die-back has to be prevented with appropriate neurotrophic factors and neurite growth inhibitory components have to be inactivated. This study may lead to further understanding of nerve fiber regeneration in the central nervous system.
Disorders of the myelin sheath
Demyelination is the loss of the myelin sheath insulating the nerves, and is the hallmark of some neurodegenerative autoimmune diseases, including multiple sclerosis, acute disseminated encephalomyelitis, transverse myelitis, chronic inflammatory demyelinating polyneuropathy, Guillain-Barré Syndrome, central pontine myelinosis, inherited demyelinating diseases such as Leukodystrophy, and Charcot Marie Tooth. Sufferers of pernicious anaemia can also suffer nerve damage if the condition is not diagnosed quickly. Sub-acute combined degeneration of the spinal cord secondary to pernicious anaemia can lead to anything from slight peripheral nerve damage to severe damage to the central nervous system, affecting speech, balance and cognitive awareness. When myelin degrades, conduction of signals along the nerve can be impaired or lost and the nerve eventually withers.
The immune system may play a role in demyelination associated with such diseases, including inflammation causing demyelination by overproduction of cytokines via upregulation of tumor necrosis factor (TNF) or interferon.
Demyelination results in diverse symptoms determined by the functions of the affected neurons. It disrupts signals between the brain and other parts of the body; symptoms differ from patient to patient, and have different presentations upon clinical observation and in laboratory studies.
Typical symptoms include:
- blurriness in the central visual field that affects only one eye; may be accompanied by pain upon eye movement;
- double vision;
- loss of vision/hearing
- odd sensation in legs, arms, chest, or face, such as tingling or numbness (neuropathy);
- weakness of arms or legs;
- cognitive disruption including speech impairment and memory loss;
- heat sensitivity (symptoms worsen, reappear upon exposure to heat such as a hot shower);
- loss of dexterity;
- difficulty coordinating movement or balance disorder;
- difficulty controlling bowel movements or urination;
Research to repair damaged myelin sheaths is ongoing. Techniques include surgically implanting oligodendrocyte precursor cells in the central nervous system and inducing myelin repair with certain antibodies. While there have been some encouraging results in mice (via stem cell transplantation), it is still unknown whether this technique can be effective in replacing myelin loss in humans. Some researchers hypothesize that cholinergic treatments, such as acetylcholinesterase inhibitors (AChEIs), may have beneficial effects on myelination, myelin repair, and myelin integrity. It is argued that increasing cholinergic stimulation also acts through subtle trophic effects on brain developmental processes and particularly on oligodendrocytes and the lifelong myelination process they support. It is possible that by increasing oligodendrocyte cholinergic stimulation, AChEIs and other cholinergic treatments like nicotine could promote myelination during development and myelin repair in older age.
Dysmyelination is characterized by a defective structure and function of myelin sheaths; unlike demyelination, it does not produce lesions. Such defective sheaths often arise from genetic mutations affecting the biosynthesis and formation of myelin. The shiverer mouse represents one animal model of dysmyelination. Human diseases where dysmyelination has been implicated include leukodystrophies (Pelizaeus-Merzbacher disease, Canavan disease, phenylketonuria) and schizophrenia.
- The Myelin Project, project to re-generate myelin
- Myelinogenesis, order of myelination of central nervous system.
- Myelin Repair Foundation, a non-profit medical research foundation accelerating drug discovery in myelin repair for multiple sclerosis.
- ^ Hartline DK, Colman DR (January 2007). "Rapid conduction and the evolution of giant axons and myelinated fibers". Curr. Biol. 17 (1): R29–35. doi:10.1016/j.cub.2006.11.042. PMID 17208176.
- ^ Virchow R (1854). "Über das ausgebreitete Vorkommen einer dem Nervenmark analogen Substanz in den tierischen Geweben". Virchows Arch. Pathol. Anat. 6: 562–72.
- ^ Ledeen RW, Chakraborty G (March 1998). "Cytokines, Signal Transduction, and Inflammatory Demyelination: Review and Hypothesis". Neurochem. Res. 23 (3): 277–89. doi:10.1023/A:1022493013904. PMID 9482240. http://www.ingentaconnect.com/content/klu/nere/1998/00000023/00000003/00421003.
- ^  FuturePundit January 20, 2004
- ^ Bartzokis, G (2007-08-15). "Acetylcholinesterase inhibitors may improve myelin integrity.". Biological Psychiatry 62 (4): 294–301. doi:10.1016/j.biopsych.2006.08.020. PMID 17070782.
- ^ Krämer-Albers EM, Gehrig-Burger K, Thiele C, Trotter J, Nave KA (November 2006). "Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia". J. Neurosci. 26 (45): 11743–52. doi:10.1523/JNEUROSCI.3581-06.2006. PMID 17093095. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17093095.
- ^ Matalon R, Michals-Matalon K, Surendran S, Tyring SK (2006). "Canavan disease: studies on the knockout mouse". Adv. Exp. Med. Biol. 576: 77–93; discussion 361–3. doi:10.1007/0-387-30172-0_6. PMID 16802706.
- ^ Tkachev D, Mimmack ML, Huffaker SJ, Ryan M, Bahn S (August 2007). "Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia". Int. J. Neuropsychopharmacol. 10 (4): 557–63. doi:10.1017/S1461145706007334. PMID 17291371. http://journals.cambridge.org/abstract_S1461145706007334.
- The Myelin Project
- Athabasca University Biological Psychology Website
- The MS Information Sourcebook, Myelin
- The Myelin Repair Foundation
- H & E Histology
- Luxol Fast Blue: Modified Kluver's Method to stain for Myelin Sheath
- Radiology and Pathology of Myelin the MedPix Medical Image Database
-  Archives of Neurology
Histology: nervous tissue (TA A14, GA 9.849, TH H2.00.06, H3.11) CNSGeneralOther PNSGeneral Neurons/
TerminationSynapse Structures of the cell membrane Membrane lipids Membrane protein locations Other Arrestin Membrane-spanning 4A Myelin Pulmonary surfactant TetraspaninTSPAN1 · TSPAN2 · TSPAN3 · TSPAN4 · TSPAN5 · TSPAN6 · TSPAN7 · TSPAN8 · TSPAN9 · TSPAN10 · TSPAN11 · TSPAN12 · TSPAN13 · TSPAN14 · TSPAN15 · TSPAN16 · TSPAN17 · TSPAN18 · TSPAN19 · TSPAN20 · TSPAN21 · TSPAN22 · TSPAN23 · TSPAN24 · TSPAN25 · TSPAN26 · TSPAN27 · TSPAN28 · TSPAN29 · TSPAN30 · TSPAN31 · TSPAN32 · TSPAN33 · TSPAN34 Other/ungrouped
Wikimedia Foundation. 2010.
Look at other dictionaries:
myelin — (n.) also myeline, soft material found in nerve tissues, 1867, from Ger. Myelin (1854), from Gk. myelos marrow; the brain, innermost part, of unknown origin … Etymology dictionary
myelin — my e*lin, myeline my e*line, n. [Gr. myelo s marrow.] (Physiol. Chem.) (a) A soft white substance constituting the medullary sheaths of nerve fibers, and composed mainly of cholesterin, lecithin, cerebrin, protein, and some fat. (b) One of a… … The Collaborative International Dictionary of English
Myelīn — (Talksteinmark), s. Steinmark … Pierer's Universal-Lexikon
Myelīn — Myelīn, Nervenmark, fettähnliche Substanz (Lecithin), in den meisten Nervenfasern der Wirbeltiere und mancher Wirbellosen … Meyers Großes Konversations-Lexikon
myelin — [mī′ə lin] n. [Ger < Gr myelos, marrow: see MYELO & INE3] the white, fatty substance forming a sheath about certain nerve fibers myelinic adj … English World dictionary
Myelin — Transmissionselektronenmikroskopisches Bild der das Axon konzentrisch umgebenden Myelinscheide Myelin ist eine lipidreiche Biomembran, welche die Axone der meisten Nervenzellen von Wirbeltieren spiralförmig umgibt und elektrisch isoliert. Myelin… … Deutsch Wikipedia
Myelin — The fatty substance that covers and protects nerves. Myelin is a layered tissue surrounding the axons or nerve fibers. The sheath around the nerve fibers which acts electrically as a conduit in an electrical system, ensuring that messages sent by … Medical dictionary
myelin — myelinic, adj. /muy euh lin/, n. Biol. a soft, white, fatty material in the membrane of Schwann cells and certain neuroglial cells: the substance of the myelin sheath. Also, myeline /muy euh leen /. [1865 70; MYEL + IN2] * * * ▪ biochemistry… … Universalium
myelin — noun Etymology: International Scientific Vocabulary Date: 1873 a soft white somewhat fatty material that forms a thick myelin sheath about the protoplasmic core of a myelinated nerve fiber • myelinic adjective … New Collegiate Dictionary
myelin — The material making up the myelin sheath of nerve axons … Dictionary of molecular biology