Chlorothiazide

Chlorothiazide
Chlorothiazide
Systematic (IUPAC) name
6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
Clinical data
Trade names Diuril
AHFS/Drugs.com monograph
MedlinePlus a682341
Pregnancy cat. C(US)
Legal status -only (US)
Routes Oral
Pharmacokinetic data
Metabolism Nil
Half-life 45 to 120 minutes
Excretion Renal
Identifiers
CAS number 58-94-6
ATC code C03AA04
PubChem CID 2720
DrugBank APRD00721
ChemSpider 2619 YesY
UNII 77W477J15H YesY
KEGG D00519 YesY
ChEBI CHEBI:3640 YesY
ChEMBL CHEMBL842 YesY
Chemical data
Formula C7H6ClN3O4S2 
Mol. mass 295.72 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive.

Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another without risk of toxicity. Because it is absorbed enterically there are no risks associated with chlorothiazide as there are with furosemide administration.

Contents

Indications

Contraindications

Dose

  • 500 mg–1 g once or twice a day, by mouth or through NG tube (reconstituted suspension)
  • May also be given intravenously, and should be given first if given in combination with IV lasix since it potentiate's the diuretic effect of furosemide.

Side effects

History

The Research team of Merck Sharp and Dohme Research Laboratories: Karl H. Beyer, Jr., M.D., Ph.D.; James M. Sprague, Ph.D.; John E. Baer, Ph.D.; and Frederick C. Novello, Ph.D. created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for its creation. http://www.laskerfoundation.org/awards/formaward.htm

Chemical

Chlorothiazide.png

Novello, Frederick C.; Sprague, James M. (1957). Journal of the American Chemical Society 79 (8): 2028. doi:10.1021/ja01565a079. 


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Look at other dictionaries:

  • chlorothiazide — ● chlorothiazide nom masculin Sulfamide du groupe des diurétiques thiazidiques, provoquant une diurèse sodique, chlorurée, potassique, légèrement bicarbonatée …   Encyclopédie Universelle

  • chlorothiazide — [klôr΄ō thī′ə zīd΄] n. [ CHLORO + THI + AZ + IDE] a synthetic drug, C7H6ClN3O4S2, used in treating hypertension, heart failure, or various edemas by removing extra salt and water through the kidneys …   English World dictionary

  • chlorothiazide sodium — [USP] the monosodium salt of chlorothiazide, having the same actions and uses as the base; administered intravenously …   Medical dictionary

  • chlorothiazide — noun Date: 1957 a thiazide diuretic C7H6ClN3O4S2 used especially in the treatment of edema and hypertension …   New Collegiate Dictionary

  • chlorothiazide — /klawr euh thuy euh zuyd , klohr /, n. Pharm. a white, crystalline, slightly water soluble powder, C7H6ClN3O4S2, used as a diuretic and in the treatment of hypertension. [1955 60; CHLORO 2 + THIAZ(OLE) + IDE] * * * …   Universalium

  • chlorothiazide — noun A thiazide diuretic used in the treatment of hypertension and other conditions …   Wiktionary

  • chlorothiazide — An orally effective diuretic inhibiting renal tubular reabsorption of sodium; used in the treatment of edema due to congestive heart failure, liver disease, pregnancy …   Medical dictionary

  • chlorothiazide — chlo·ro·thiazide …   English syllables

  • chlorothiazide — chlo•ro•thi•a•zide [[t]ˌklɔr əˈθaɪ əˌzaɪd, ˌkloʊr [/t]] n. pha a white, crystalline, slightly water soluble powder, C7H6ClN3O4S2, used as a diuretic and in treating hypertension • Etymology: 1955–60; chloro II+thiaz ( ole) + ide …   From formal English to slang

  • chlorothiazide — noun a diuretic drug (trade name Diuril) used in the treatment of edema and hypertension (Freq. 2) • Syn: ↑Diuril • Usage Domain: ↑trade name (for: ↑Diuril) • Hypernyms: ↑ …   Useful english dictionary

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