Cicletanine

Cicletanine

Systematic (IUPAC) name
3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Pharmacokinetic data
Protein binding	97.3%
Half-life	7.9 h
Identifiers
CAS number	89943-82-8
ATC code	C03BX03
PubChem	CID 54910
ChemSpider	49583 Y
UNII	CHG7QC509W Y
KEGG	D03487 Y
ChEMBL	CHEMBL191886 Y
Chemical data
Formula	C14H12ClNO2
Mol. mass	261.703 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3 Y Key:CVKNDPRBJVBDSS-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.^[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.^[2]

Mechanism

It can inhibit protein kinase C.^[3]

References

1. ^ Jean Sassard (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 9780861963133. http://books.google.com/?id=v4E_g_D6xCwC&pg=PA547&lpg=PA547&dq=Cicletanine 
2. ^ Bagrov AY, Dmitrieva RI, Dorofeeva NA et al. (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". J. Hypertens. 18 (2): 209–15. doi:10.1097/00004872-200018020-00012. PMID 10694190. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0263-6352&volume=18&issue=2&spage=209. 
3. ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension 41 (3): 505–11. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951. http://hyper.ahajournals.org/cgi/pmidlookup?view=long&pmid=12623951. 

External links

• Ipsen Corporation

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