Indapamide

Indapamide: Indapamide

Systematic (IUPAC) name

4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide

Clinical data

AHFS/Drugs.com monograph

MedlinePlus a684062

Pregnancy cat. ?

Legal status POM

Routes Oral tablet

Pharmacokinetic data

Protein binding 71-79%

Metabolism Hepatic

Half-life 14-18 hours

Identifiers

CAS number 26807-65-8^Y

ATC code C03BA11

PubChem CID 3702

DrugBank APRD01031

ChemSpider 3574^Y

UNII F089I0511L^Y

KEGG D00345^Y

ChEMBL CHEMBL406^Y

Chemical data

Formula C₁₆H₁₆Cl N₃O₃S

Mol. mass 365.835 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)^Y
Key:NDDAHWYSQHTHNT-UHFFFAOYSA-N^Y

N(what is this?) (verify)

Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol.^[1] Indapamide is marketed as Natrilix outside of the US, as Insig in Australia. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

It is described as a thiazide-like diuretic.^[2]

Contents

1 Form and composition

2 Indications

3 Dosage and administration

4 Contraindications

5 Interactions

6 Precautions

7 Adverse effects

8 Overdosage

9 References

Form and composition

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.^[3]

Indications

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without perindopril to people over the age of 80 for the treatment of hypertension.

Dosage and administration

The adult dosage is 1.25 to 5 mg by orally once daily usually in the morning.

Contraindications

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure and hypokalemia (low blood potassium levels).

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

Interactions

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

Overdosage

Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.

References

^ http://www.rxlist.com/lozol-drug.htm

^ MeSH Indapamide

^ http://online.lexi.com/crlsql/servlet/crlonline

v · d · eAntihypertensives: diuretics (C03)

Sulfonamides
(except EA)

CA inhibitors (at PT)

Acetazolamide

Loop (Na-K-Cl at AL)

Furosemide^# • Bumetanide • Torasemide • Etacrynic acid

Thiazides (Na-Cl at DCT,
Calcium-sparing)

Hydrochlorothiazide^# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide

Thiazide-likes (primarily DCT)

Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone

Potassium-sparing (at CD)

ESC blockers

Amiloride^# • Triamterene • Benzamil

Aldosterone antagonists

Spironolactone^# • Eplerenone • Potassium canrenoate • Canrenone

Osmotic diuretics (PT, DL)
Mannitol^# • Urea

VAs (DCT and CD)

vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan
tetracyclines: Demeclocycline

Other
mercurial diuretic (Mersalyl) • Theobromine • Cicletanine

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

Categories:
Thiazides
Diuretics
Benzamides
Indoles
Organochlorides
Servier

Indapamide

Systematic (IUPAC) name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a684062
Pregnancy cat.	?
Legal status	POM
Routes	Oral tablet
Pharmacokinetic data
Protein binding	71-79%
Metabolism	Hepatic
Half-life	14-18 hours
Identifiers
CAS number	26807-65-8^Y
ATC code	C03BA11
PubChem	CID 3702
DrugBank	APRD01031
ChemSpider	3574^Y
UNII	F089I0511L^Y
KEGG	D00345^Y
ChEMBL	CHEMBL406^Y
Chemical data
Formula	C₁₆H₁₆Cl N₃O₃S
Mol. mass	365.835 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)^Y Key:NDDAHWYSQHTHNT-UHFFFAOYSA-N^Y
N(what is this?) (verify)

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indapamide — noun diuretic (trade name Lozal) used in the treatment of hypertension • Syn: ↑Lozal • Usage Domain: ↑trade name (for: ↑Lozal) • Hypernyms: ↑diuretic drug, ↑ … Useful english dictionary
Indapamide — ИНДАПАМИД ( Indараmidе )*. 4 Хлор N (2 метил 1 индолинил) 3 сульфамоил бензамид. Синонимы: Аrifоn, Еxtur, Fludeх, Indaflех, Ipamix, Lоrvаs, Меtindamide, Nаtriliх, Таndiх и др. По структуре и действию близок к клопамиду; является его индолинильным … Словарь медицинских препаратов
indapamide — /in dap euh muyd /, n. Pharm. a thiazide related compound, C16H16ClN3O3S, used in the treatment of hypertension and edema. [ind(oline) (see INDOLE, INE2) + ap of uncert. derivation + AMIDE] * * * … Universalium
indapamide — noun A particular sulphonamide diuretic drug … Wiktionary
indapamide — in·dap·a·mide (in dapґə mīd) [USP] an antihypertensive and diuretic with actions and uses similar to those of chlorothiazide; administered orally either alone or in combination with other antihypertensive agents … Medical dictionary
Perindopril/indapamide — Combination of Perindopril ACE inhibitor Indapamide diuretic Clinical data Pregnancy cat. ? Legal status Prescription Only (S4) ( … Wikipedia
Metolazone — Systematic (IUPAC) name 7 chloro 2 methyl 4 oxo 3 o tolyl 1,2,3,4 tetrahydroquinazoline 6 sulfonamide Clinical data Trade names … Wikipedia
Perindopril — Systematic (IUPAC) name (2S,3aS,7aS) 1 [(2S) 2 {[(2S) 1 ethoxy 1 oxopentan 2 yl]amino}propanoyl] octahydro 1H indole 2 carboxylic acid Clinical data … Wikipedia
Diuretic — This illustration shows where some types of diuretics act, and what they do. A diuretic provides a means of forced diuresis which elevates the rate of urination. There are several categories of diuretics. All diuretics increase the excretion of… … Wikipedia
Sulfonamide (medicine) — There are several sulfonamide based groups of drugs. The original antibacterial sulfonamides (sometimes called simply sulfa drugs) are synthetic antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of… … Wikipedia

Academic Dictionaries and Encyclopedias

Indapamide

Contents

Form and composition

Indications

Dosage and administration

Contraindications

Interactions

Precautions

Adverse effects

Overdosage

References

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Indapamide

Contents

Form and composition

Indications

Dosage and administration

Contraindications

Interactions

Precautions

Adverse effects

Overdosage

References

Look at other dictionaries:

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