SLC22A4

Solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Identifiers
Symbols	SLC22A4; MGC34546; MGC40524; OCTN1
External IDs	OMIM: 604190 MGI: 1353479 HomoloGene: 81701 GeneCards: SLC22A4 Gene
Gene Ontology Molecular function • nucleotide binding • protein binding • ATP binding • secondary active organic cation transmembrane transporter activity • ion transmembrane transporter activity • carnitine transporter activity • symporter activity • cation:cation antiporter activity • quaternary ammonium group transmembrane transporter activity • transmembrane transporter activity • PDZ domain binding Cellular component • mitochondrion • plasma membrane • plasma membrane • integral to plasma membrane • apical plasma membrane Biological process • triglyceride metabolic process • sodium ion transport • body fluid secretion • carnitine metabolic process • organic cation transport • quaternary ammonium group transport • carnitine transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6583	30805
Ensembl	ENSG00000197208	ENSMUSG00000020334
UniProt	Q9H015	Q5SWV1
RefSeq (mRNA)	NM_003059	NM_019687.3
RefSeq (protein)	NP_003050	NP_062661.1
Location (UCSC)	Chr 5: 131.63 – 131.68 Mb	Chr 11: 53.8 – 53.84 Mb
PubMed search	[1]	[2]

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is an ergothioneine transporter.^[1]

Function

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low.^[2] The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.^[3] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").

Interactions

SLC22A4 has been shown to interact with PDZK1.^[4]

See also

• Solute carrier family

References

1. ^ "Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583. 
2. ^ Grigat S, Harlfinger S, Pal S, et al. (2007). "Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations". Biochem. Pharmacol. 74 (2): 309–16. doi:10.1016/j.bcp.2007.04.015. PMID 17532304. 
3. ^ Gründemann D, Harlfinger S, Golz S, et al. (2005). "Discovery of the ergothioneine transporter". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5256–61. doi:10.1073/pnas.0408624102. PMC 555966. PMID 15795384. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=555966. 
4. ^ Gisler, Serge M; Pribanic Sandra, Bacic Desa, Forrer Patrik, Gantenbein Andrea, Sabourin Luc A, Tsuji Akira, Zhao Zhuo-Shen, Manser Edward, Biber Jürg, Murer Heini (Nov. 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. (United States) 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. ISSN 0085-2538. PMID 14531806. 

Further reading

• Xuan W, Lamhonwah AM, Librach C, et al. (2003). "Characterization of organic cation/carnitine transporter family in human sperm". Biochem. Biophys. Res. Commun. 306 (1): 121–8. doi:10.1016/S0006-291X(03)00930-6. PMID 12788076. 
• Yamada R, Tokuhiro S, Chang X, Yamamoto K (2005). "SLC22A4 and RUNX1: identification of RA susceptible genes". J. Mol. Med. 82 (9): 558–64. doi:10.1007/s00109-004-0547-y. PMID 15184985. 
• Silverberg MS (2006). "OCTNs: will the real IBD5 gene please stand up?". World J. Gastroenterol. 12 (23): 3678–81. PMID 16773684. 
• Tamai I, Yabuuchi H, Nezu J, et al. (1998). "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1". FEBS Lett. 419 (1): 107–11. doi:10.1016/S0014-5793(97)01441-5. PMID 9426230. 
• Meyer-Wentrup F, Karbach U, Gorboulev V, et al. (1998). "Membrane localization of the electrogenic cation transporter rOCT1 in rat liver". Biochem. Biophys. Res. Commun. 248 (3): 673–8. doi:10.1006/bbrc.1998.9034. PMID 9703985. 
• Urakami Y, Okuda M, Masuda S, et al. (1998). "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs". J. Pharmacol. Exp. Ther. 287 (2): 800–5. PMID 9808712. 
• Yabuuchi H, Tamai I, Nezu J, et al. (1999). "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations". J. Pharmacol. Exp. Ther. 289 (2): 768–73. PMID 10215651. 
• Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. 
• Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population". J. Hum. Genet. 47 (11): 576–84. doi:10.1007/s100380200088. PMID 12436193. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Eraly SA, Hamilton BA, Nigam SK (2003). "Organic anion and cation transporters occur in pairs of similar and similarly expressed genes". Biochem. Biophys. Res. Commun. 300 (2): 333–42. doi:10.1016/S0006-291X(02)02853-X. PMID 12504088. 
• Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806. 
• Tokuhiro S, Yamada R, Chang X, et al. (2004). "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis". Nat. Genet. 35 (4): 341–8. doi:10.1038/ng1267. PMID 14608356. 
• Peltekova VD, Wintle RF, Rubin LA, et al. (2004). "Functional variants of OCTN cation transporter genes are associated with Crohn disease". Nat. Genet. 36 (5): 471–5. doi:10.1038/ng1339. PMID 15107849. 
• Kawasaki Y, Kato Y, Sai Y, Tsuji A (2005). "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population". Journal of pharmaceutical sciences 93 (12): 2920–6. doi:10.1002/jps.20190. PMID 15459889. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Newman B, Gu X, Wintle R, et al. (2005). "A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease". Gastroenterology 128 (2): 260–9. doi:10.1053/j.gastro.2004.11.056. PMID 15685536. 

SLC11–20
(11) proton coupled metal ion transporter (SLC11A1, SLC11A2) 11A3 (12) electroneutral cation-Cl cotransporter (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9) (13) human Na+-sulfate/carboxylate cotransporter (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5) (14) urea transporter (SLC14A1, SLC14A2) (15) proton oligopeptide cotransporter (SLC15A1, SLC15A2, SLC15A3, SLC15A4) (16) monocarboxylate transporter (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14) (17) vesicular glutamate transporter (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9) (18) vesicular amine transporter (SLC18A1, SLC18A2, SLC18A3) (19) folate/thiamine transporter (SLC19A1, SLC19A2, SLC19A3) (20) type III Na+-phosphate cotransporter (SLC20A1, SLC20A2)

SLC21–30
(21) organic anion transporting (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1B4, SLCO1C1) (SLCO2A1, SLCO2B1) (SLCO3A1) (SLCO4A1, SLCO4C1) (SLCO5A1) (SLCO6A1) (22) organic cation/anion/zwitterion transporter (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A19, SLC22A20) (23) Na+-dependent ascorbic acid transporter (SLC23A1, SLC23A2, SLC23A3, SLC23A4) (24) Na+/(Ca2+-K+) exchanger (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6) (25) mitochondrial carrier (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLC25A7, SLC25A8, SLC25A9, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46) (26) multifunctional anion exchanger (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11) (27) fatty acid transport proteins (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6) (28) Na+-coupled nucleoside transport (SLC28A1, SLC28A2, SLC28A3 (29) facilitative nucleoside transporter (SLC29A1, SLC29A2, SLC29A3, SLC29A4) (30) zinc efflux (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)

SLC31–40
(31) copper transporter (SLC31A1) (32) vesicular inhibitory amino-acid transporter (SLC32A1) (33) Acetyl-CoA transporter (SLC33A1) (34) type II Na+-phosphate cotransporter (SLC34A1, SLC34A2, SLC34A3) (35) nucleoside-sugar transporter (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5) (SLC35B1, SLC35B2, SLC35B3, SLC35B4) (SLC35C1, SLC35C2) (SLC35D1, SLC35D2, SLC35D3) (SLC35E1, SLC35E2, SLC35E3, SLC35E4) (36) proton-coupled amino-acid transporter (SLC36A1, SLC36A2, SLC36A3, SLC36A4)36A2 · (37) sugar-phosphate/phosphate exchanger (SLC37A1, SLC37A2, SLC37A3, SLC37A4) (38) System A & N, sodium-coupled neutral amino-acid transporter (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A10) (39) metal ion transporter (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14) (40) basolateral iron transporter (SLC40A1)

SLC41–48
(41) MgtE-like magnesium transporter (SLC41A1, SLC41A2, SLC41A3) (42) Ammonia transporter (RhAG, RhBG, RhCG) (43) Na+-independent, system-L like amino-acid transporter (SLC43A1, SLC43A2, SLC43A3) (44) Choline-like transporter (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5) (45) Putative sugar transporter (SLC45A1, SLC45A2, SLC54A3, SLC45A4) (46) Folate transporter (SLC46A1, SLC46A2) (47) multidrug and toxin extrusion (SLC47A1, SLC47A2) (48) Heme transporter

SLCO1–4
O1A2 · O1B1 · O1B3 · O2B1 · O431 · O4A1

Ion pumps
Symporter, Cotransporter Na+/K+/2Cl- - Na/Pi3 - Na+/Cl- - Na/glucose - Na+/I- - Cl-/K+ (4, 5) Antiporter (exchanger) Na+/H+ - Na+/Ca2+ (Na+/(Ca2+-K+)) - Cl-/HCO3- (Band 3) - Cl-formate exchanger - Cl-oxalate exchanger

see also solute carrier disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr