Poly(A) binding protein, cytoplasmic 1

PDB rendering based on 1cvj.
External IDs OMIM604679 MGI1349722 HomoloGene37638 GeneCards: PABPC1 Gene
Species Human Mouse
Entrez 26986 18458
Ensembl ENSG00000070756 ENSMUSG00000022283
UniProt P11940 n/a
RefSeq (mRNA) NM_002568.3 NM_008774.3
RefSeq (protein) NP_002559.2 NP_032800.2
Location (UCSC) Chr 8:
101.7 – 101.74 Mb
Chr 15:
36.53 – 36.54 Mb
PubMed search [1] [2]

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene.[1]

The poly(A)-binding protein (PAB or PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.[supplied by OMIM][2]


PABPC1 has been shown to interact with ANAPC5,[3] GSPT2,[4] CNOT7,[5] PAIP1,[6][7] Eukaryotic translation initiation factor 4 gamma,[8] EIF4G3[8] and PAIP2.[9]


  1. ^ Grange T, de Sa CM, Oddos J, Pictet R (Aug 1987). "Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif". Nucleic Acids Res 15 (12): 4771–87. doi:10.1093/nar/15.12.4771. PMC 305917. PMID 2885805. 
  2. ^ "Entrez Gene: PABPC1 poly(A) binding protein, cytoplasmic 1". 
  3. ^ Koloteva-Levine, Nadejda; Pinchasi Dalia, Pereman Idan, Zur Amit, Brandeis Michael, Elroy-Stein Orna (May. 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. (United States) 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755. 
  4. ^ Hoshino, S; Imai M, Kobayashi T, Uchida N, Katada T (Jun. 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. (UNITED STATES) 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005. 
  5. ^ Funakoshi, Yuji; Doi Yusuke, Hosoda Nao, Uchida Naoyuki, Osawa Masanori, Shimada Ichio, Tsujimoto Masafumi, Suzuki Tsutomu, Katada Toshiaki, Hoshino Shin-ichi (Dec. 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. (United States) 21 (23): 3135–48. doi:10.1101/gad.1597707. ISSN 0890-9369. PMC 2081979. PMID 18056425. 
  6. ^ Roy, Guylaine; De Crescenzo Gregory, Khaleghpour Kianoush, Kahvejian Avak, O'Connor-McCourt Maureen, Sonenberg Nahum (Jun. 2002). "Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs". Mol. Cell. Biol. (United States) 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. ISSN 0270-7306. PMC 133836. PMID 11997512. 
  7. ^ Craig, A W; Haghighat A, Yu A T, Sonenberg N (Apr. 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature (ENGLAND) 392 (6675): 520–3. doi:10.1038/33198. ISSN 0028-0836. PMID 9548260. 
  8. ^ a b Imataka, H; Gradi A, Sonenberg N (Dec. 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. (ENGLAND) 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. ISSN 0261-4189. PMC 1171091. PMID 9857202. 
  9. ^ Khaleghpour, K; Kahvejian A, De Crescenzo G, Roy G, Svitkin Y V, Imataka H, O'Connor-McCourt M, Sonenberg N (Aug. 2001). "Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein". Mol. Cell. Biol. (United States) 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. ISSN 0270-7306. PMC 87244. PMID 11438674. 

Further reading

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