Methylprednisolone

Methylprednisolone
Methylprednisolone
Systematic (IUPAC) name
(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
Trade names Medrol, Meprolone
AHFS/Drugs.com monograph
MedlinePlus a682795
Licence data US FDA:link
Pregnancy cat. A(AU) C(US)
Legal status POM (UK) -only (US)
Routes IV, IM, IV Infusion, Oral, Rectal, Topical
Pharmacokinetic data
Protein binding 78%
Metabolism liver primarily, kidney, tissues; CYP450: 3A4 substrate
Half-life urine; Half-life: 18-26h (biological)
Identifiers
CAS number 83-43-2 YesY
ATC code D07AA01 D07AC14, D10AA02, H02AB04
PubChem CID 6741
DrugBank APRD00342
ChemSpider 6485 YesY
UNII X4W7ZR7023 YesY
KEGG D00407 YesY
ChEBI CHEBI:6888 YesY
ChEMBL CHEMBL650 YesY
Synonyms (6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
Chemical data
Formula C22H30O5 
Mol. mass 374.471 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol.[1] It is also available as a generic drug.

It is a variant of prednisolone, methylated at carbon 6 of the B ring.

Contents

Uses

Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably Systemic lupus erythematosus. Also for use as a treatment for Multiple Sclerosis.

Methylprednisolone is also prescribed for nonpenetrating spinal cord injuries. It has been shown that a dose of 30 mg/kg IV followed by IV drip at 5.4 mg/kg/hr for 23 hours improves sensory and motor recovery if given within eight hours of the injury.[citation needed]

Methylprednisolone can be injected into the spinal cord by pain management specialists for the treatment of chronic pain caused by injuries or osteoarthritis.

It is also used for vestibular neuritis.[2]

Side effects

Methylprednisolone has some serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause sleeplessness and "down" moods.

Additional images

See also

References

  1. ^ Methylprednisolone - Compound Summary PubChem
  2. ^ Strupp M, Zingler VC, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T (July 2004). "Methylprednisolone, valacyclovir, or the combination for vestibular neuritis" (PDF). N. Engl. J. Med. 351 (4): 354–61. doi:10.1056/NEJMoa033280. PMID 15269315. http://www.nejm.org/doi/pdf/10.1056/NEJMoa033280. 

External links


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  • Méthylprednisolone — Général No CAS …   Wikipédia en Français

  • Methylprednisolone aceponate — Clinical data AHFS/Drugs.com …   Wikipedia

  • methylprednisolone sodium succinate — [USP] the 21 succinate sodium salt of methylprednisolone, having actions and uses similar to those of the base; it is highly soluble in water and is chiefly used for the rapid achievement of high blood levels of methylprednisolone in short term… …   Medical dictionary

  • methylprednisolone acetate — [USP] the 21 acetate ester of methylprednisolone, administered topically as an antiinflammatory, by intramuscular injection in replacement therapy for adrenocortical insufficiency, and by intra articular, intramuscular, intralesional, or soft… …   Medical dictionary

  • methylprednisolone hemisuccinate — [USP] the hemisuccinate salt of methylprednisolone, having actions and uses similar to those of the base …   Medical dictionary

  • methylprednisolone — noun Date: 1957 a glucocorticoid C22H30O5 that is a derivative of prednisolone and is used as an anti inflammatory agent; also any of several of its salts (as an acetate) used similarly …   New Collegiate Dictionary

  • methylprednisolone — meth·yl·pred·nis·o·lone (mĕth əl prĕd nĭsʹə lōn ) n. A glucocorticoid used therapeutically primarily as an anti inflammatory agent. * * * …   Universalium

  • methylprednisolone — noun A synthetic glucocorticoid drug, with chemical formula CHO …   Wiktionary

  • methylprednisolone — An anti inflammatory glucocorticoid. m. acetate has the same actions and uses as m.; aqueous suspensions are suitable for intrasynovial and soft tissue injection. sodium m. succinate it has the same metabolic and anti inflammatory actions as the… …   Medical dictionary

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