Terfenadine

Terfenadine
Terfenadine
Systematic (IUPAC) name
(RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol
Clinical data
AHFS/Drugs.com Multum Consumer Information
MedlinePlus a600034
Pregnancy cat.  ?
Legal status Withdrawn
Pharmacokinetic data
Protein binding 70%
Half-life 3.5 hours
Identifiers
CAS number 50679-08-8 YesY
ATC code R06AX12
PubChem CID 5405
DrugBank APRD00606
ChemSpider 5212 YesY
UNII 7BA5G9Y06Q YesY
KEGG D00521 YesY
ChEMBL CHEMBL17157 YesY
Chemical data
Formula C32H41NO2 
Mol. mass 471.673 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and marketed under various brand names including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. According to its manufacturer, terfenadine had been used by over 100 million patients worldwide as of 1990.[1] It was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.

Terfenadine is a prodrug, generally completely metabolised to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses while its major, active metabolite is not. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods like grapefruit. The addition of, or dosage change in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, terfenadine may lead to toxic effects on the heart's rhythm (e.g. ventricular tachycardia and torsades de pointes).

History

In the United States, Seldane was brought to market in 1985 as the first non-sedating antihistamine for the treatment of allergic rhinitis.[1][2] In June 1990, evidence of serious ventricular arrhythmias among those taking Seldane prompted the FDA to issue a report on the risk factors associated with concomitant use of the drug with macrolide antibiotics and ketoconazole.[1] Two months later, the FDA required the manufacturer to send a letter to all physicians, alerting them to the problem; in July 1992 the existing precautions were elevated to a black box warning[1] and the issue attracted mass media attention in reports that people with liver disease or who took ketoconazole, an antifungal agent, or the antibiotic erythromycin, could suffer cardiac arrhythmia if they also took Seldane.[2]

In January 1997, the same month when the U.S. Food and Drug Administration (FDA) had earlier approved a generic version of Seldane made by IVAX Corporation of Miami, the FDA recommended that terfenadine-containing drugs be removed from the market and that physicians consider alternative medications for their patients.[2] Seldane (and Seldane-D, terfenadine combined with the decongestant pseudoephedrine) were removed from the U.S. market by their manufacturer in late 1997 after the FDA approval of Allegra-D (fexofenadine/pseudoephedrine).[3] Terfenadine-containing drugs were subsequently removed from the Canadian market in 1999,[4] and are no longer available for prescription in the UK.[5]

References

External links


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Look at other dictionaries:

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  • terfenadine — noun An antihistamine drug formerly used to treat allergic conditions, superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia …   Wiktionary

  • terfenadine — An H1 antihistamine used to treat a variety of allergic conditions; has fewer sedative effects than other antihistamines, but in combination with several other drugs may cause serious cardiac arrhythmias. * * * ter·fen·a·dine (.)tər fen ə .dēn n… …   Medical dictionary

  • terfénadine —  n.f. Médicament antiallergique …   Le dictionnaire des mots absents des autres dictionnaires

  • Терфенадин (Terfenadine) — антигистаминный препарат; применяется для лечения сенной лихорадки и устранения ее проявлений (чиханье, зуд и слезотечение).Назначается внутрь; возможные побочные эффекты: сонливость, головные боли и нарушения деятельности желудочно кишечного… …   Медицинские термины

  • ТЕРФЕНАДИН — (terfenadine) антигистаминный препарат; применяется для лечения сенной лихорадки и устранения ее проявлений (чиханье, зуд и слезотечение).Назначается внутрь; возможные побочные эффекты: сонливость, головные боли и нарушения деятельности желудочно …   Толковый словарь по медицине

  • H1 antagonist — An H1 antagonist is a histamine antagonist of the H1 receptor that serves to reduce or eliminate effects mediated by histamine, an endogenous chemical mediator released during allergic reactions. Agents where the main therapeutic effect is… …   Wikipedia

  • Fexofenadine — Drugbox IUPAC name = 2 [4 [1 hydroxy 4 [4 (hydroxy diphenyl methyl) 1 piperidyl] butyl] phenyl] 2 methyl propanoic acid width= 200px CAS number= 153439 40 8 ATC prefix= R06 ATC suffix= A626 ATC supplemental= PubChem= 3348 DrugBank= APRD00349 C=32 …   Wikipedia

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  • Astemizole — Systematic (IUPAC) name 1 [(4 fluorophenyl)methyl] N [1 [2 (4 methoxyphenyl)ethyl] 4 piperidyl]benzoimidazol 2 amine Clinical data AHFS/ …   Wikipedia

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