Ethyl methanesulfonate


Ethyl methanesulfonate

chembox new
Reference = ["Merck Index", 11th Edition, 3782.]
ImageFile = ethyl methanesulfonate.png ImageSize = 150px
IUPACName = 1-Methylsulfonyloxyethane
OtherNames = Ethyl mesylate
Ethyl methanesulphonate
Section1 = Chembox Identifiers
Abbreviations = EMS
CASNo = 62-50-0
EINECS =
PubChem = 6113
SMILES = CCOS(=O)(=O)C
InChI = 1/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3
RTECS =
MeSHName =
ChEBI =
KEGG =
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Section2 = Chembox Properties
C=3|H=8|O=3|S=1
MolarMass =124.16 g/mol
Appearance = Clear colorless liquid
Density = 1.1452 at 22 °C
MeltingPt = <25 °C
Melting_notes =
BoilingPt = 213-213.5 °C
Boiling_notes =
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Solvent =
pKa =
pKb =

Section7 = Chembox Hazards
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NFPA-H = 1
NFPA-F = 1
NFPA-R = 0
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Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, and possibly carcinogenic organic compound with formula carbon3hydrogen8oxygen3sulfur. It produces random mutations in genetic material by nucleotide substitution; specifically by guanine alkylation. This typically produces only point mutations. It can induce mutations at a rate of 5x10-4 to 5x10-2 per gene without substantial killing. The ethyl group of EMS reacts with guanine in DNA, forming the abnormal base O-6-ethylguanine. During DNA replication, DNA polymerases that catalyze the process frequently place thymine, instead of cytosine, opposite O-6-ethylguanine. Following subsequent rounds of replication, the original G:C base pair can become an A:T pair. This changes the genetic information, is often harmful to cells, and can result in disease. Many mutagens cause a wide variety of cancers in humans.

EMS is often used in genetics as a mutagen. Mutations induced by EMS can then be studied in genetic screens or other assays.

Popular culture

In the 1982 movie Blade Runner, replicant Roy Batty asks Dr. Eldon Tyrell about thepossibility of extending his preprogrammed lifespan by changing his genetic code with "EMS recombination". He is informed that ethyl methanesulfonate is a potent mutagen and that a test subject was "dead before he left the table."

References

External links


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