NANS

NANS
N-acetylneuraminic acid synthase

PDB rendering based on 1wvo.
Identifiers
Symbols NANS; SAS
External IDs OMIM605202 MGI2149820 HomoloGene10343 GeneCards: NANS Gene
RNA expression pattern
PBB GE NANS 218189 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54187 94181
Ensembl ENSG00000095380 ENSMUSG00000028334
UniProt Q9NR45 n/a
RefSeq (mRNA) NM_018946 NM_053179.3
RefSeq (protein) NP_061819 NP_444409.1
Location (UCSC) Chr 9:
100.82 – 100.85 Mb
Chr 4:
46.5 – 46.52 Mb
PubMed search [1] [2]

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.[1][2]

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product.

In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.[2]

References

  1. ^ Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (Jul 2000). "Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability". J Biol Chem 275 (23): 17869–77. doi:10.1074/jbc.M000217200. PMID 10749855. 
  2. ^ a b "Entrez Gene: NANS N-acetylneuraminic acid synthase (sialic acid synthase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54187. 

Further reading



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  • Nans — is the name or part of the name of several communes in France: Nans, Doubs Les Nans, Jura Nans les Pins, Var Nans sous Sainte Anne, Doubs Nans and the four letter acronym NANS can also refer to: N acetylneuraminic acid synthase a signalling NaN… …   Wikipedia

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  • Nans — 47° 28′ 39″ N 6° 24′ 45″ E / 47.4775, 6.4125 …   Wikipédia en Français

  • Nans — Der Name Nans bezeichnet: Nans (Doubs), Gemeinde im französischen Département Doubs Les Nans, Gemeinde im französischen Département Jura Nans les Pins, Gemeinde im französischen Département Var Nans sous Sainte Anne, Gemeinde im französischen… …   Deutsch Wikipedia

  • nans — ex·pla·nans; …   English syllables

  • Nans (Doubs) — Nans …   Deutsch Wikipedia

  • Nans-sous-Sainte-Anne — Nans sous Sainte Anne …   Deutsch Wikipedia

  • Nans-Les-Pins — Pays   …   Wikipédia en Français

  • Nans-les-pins — Pays   …   Wikipédia en Français

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