NAB2

NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
Identifiers
Symbols NAB2; MADER; MGC75085
External IDs OMIM602381 MGI107563 HomoloGene4353 GeneCards: NAB2 Gene
RNA expression pattern
PBB GE NAB2 212803 at tn.png
PBB GE NAB2 216017 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4665 17937
Ensembl ENSG00000166886 ENSMUSG00000025402
UniProt Q15742 Q3TBL2
RefSeq (mRNA) NM_005967 NM_008668
RefSeq (protein) NP_005958 NP_032694
Location (UCSC) Chr 12:
57.48 – 57.49 Mb
Chr 10:
127.1 – 127.11 Mb
PubMed search [1] [2]

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.[1][2][3]

Function

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

References

  1. ^ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol 16 (7): 3545–53. PMC 231349. PMID 8668170. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231349. 
  2. ^ Kirsch KH, Korradi Y, Johnson JP (Jul 1996). "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene 12 (5): 963–71. PMID 8649813. 
  3. ^ a b "Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4665. 

Further reading


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  • NAB1 — NGFI A binding protein 1 (EGR1 binding protein 1) Identifiers Symbols NAB1; External IDs …   Wikipedia

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